PMID: 16538110Mar 16, 2006Paper

Aspartate aminotransferase to platelet ratio index for fibrosis evaluation in chronic viral hepatitis

European Journal of Gastroenterology & Hepatology
Nikolaos V ChrysanthosAthanasios J Archimandritis

Abstract

We assessed the value of the recently developed aspartate aminotransferase to platelet ratio index (APRI) for predicting significant fibrosis or cirrhosis in patients with chronic hepatitis C or HBeAg-negative chronic hepatitis B. In total, 489 patients (chronic hepatitis C, 284 patients; HBeAg-negative chronic hepatitis B, 205 patients) were included. APRI values of 0.50 or less and greater than 1.50 were evaluated for predicting significant fibrosis, and APRI values of 1.00 or less and greater than 2.00 for predicting cirrhosis. Liver biopsies were evaluated according to the Ishak's classification. Fibrosis was considered to be significant in cases with scores 3-6, and cirrhosis to be present in cases with fibrosis scores of 5 and 6. Significant fibrosis was observed in 56/148 (38%) patients with APRI< or = 0.50, 130/227 (57%) patients with 0.50<APRI< or = 1.50 and 84/114 (74%) patients with APRI>1.50 (P<10). Cirrhosis was observed in 47/311 (15%) patients with APRI< or = 1.00, 29/93 (31%) patients with 1.00<APRI< or = 2.00 and 37/85 (44%) patients with APRI>2.00 (P<10). The areas under receiver-operating characteristic curves were 0.65 and 0.70 for prediction of significant fibrosis or cirrhosis, respectively. The combinatio...Continue Reading

References

Jun 1, 1995·Journal of Hepatology·K IshakR N MacSween
Jan 15, 1993·Annals of Internal Medicine·G Garcia-Tsao, J L Boyer
Feb 3, 1998·The American Journal of Gastroenterology·S G ShethS Chopra
May 8, 1999·Alimentary Pharmacology & Therapeutics·G V PapatheodoridisA K Burroughs
Jul 15, 2000·Seminars in Liver Disease·T PoynardP Opolon
Feb 15, 2001·The New England Journal of Medicine·A A BravoS Chopra
Jul 3, 2002·Annals of Internal Medicine·Daniele PratiGirolamo Sirchia
Sep 26, 2002·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Xavier FornsJuan Rodés
Oct 19, 2002·The American Journal of Gastroenterology·Vivek KaulKenneth D Rothstein
Oct 31, 2002·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Robert J Fontana, Anna S F Lok
Oct 31, 2002·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Jules L Dienstag
Jul 29, 2003·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Thierry PoynardJanice Albrecht
Jul 29, 2003·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Chun-Tao WaiAnna S-F Lok
Oct 28, 2003·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Edoardo Giannini, Roberto Testa
Dec 4, 2003·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Peter J Scheuer
Dec 23, 2003·Alimentary Pharmacology & Therapeutics·G V Papatheodoridis, S J Hadziyannis
Mar 5, 2004·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Sophie Le CalvezThierry Poynard
May 4, 2004·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Archana SudJacob George
Jul 3, 2004·Journal of Viral Hepatitis·G V Papatheodoridis, E Cholongitas
May 26, 2005·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Carolin LacknerRudolf E Stauber
Aug 27, 2005·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Cosimo CollettaMario Pirisi

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Citations

Sep 15, 2010·International Journal of Obesity : Journal of the International Association for the Study of Obesity·K Widhalm, E Ghods
Mar 27, 2010·Saudi Journal of Gastroenterology : Official Journal of the Saudi Gastroenterology Association·Faisal M Sanai, Emmet B Keeffe
Nov 28, 2013·BioMed Research International·Gaetano BertinoMassimo Motta
Nov 9, 2010·Journal of Biomedical Optics·Yuting HeHanry Yu
Apr 30, 2013·Arab Journal of Gastroenterology : the Official Publication of the Pan-Arab Association of Gastroenterology·Omayma SalehMohamed S Abdel-Rahman
Feb 5, 2009·Liver International : Official Journal of the International Association for the Study of the Liver·Jung Won YunJun Ho Shin
Jun 13, 2009·Alimentary Pharmacology & Therapeutics·J O Smith, R K Sterling
Nov 8, 2012·Hepatology Research : the Official Journal of the Japan Society of Hepatology·Kenji IkedaHiromitsu Kumada
Feb 14, 2013·Liver International : Official Journal of the International Association for the Study of the Liver·Nathalie SturmVincent Leroy
Feb 15, 2011·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Zhong-Hua LinShi-Ying Xuan
Aug 15, 2013·Hepatology Research : the Official Journal of the Japan Society of Hepatology·Kenji IkedaHiromitsu Kumada
May 31, 2015·International Urology and Nephrology·Olga Hilda OrăşanDan Lucian Dumitraşcu
Oct 22, 2010·The Brazilian Journal of Infectious Diseases : an Official Publication of the Brazilian Society of Infectious Diseases·Renata Eliane de AvilaJosé Roberto Lambertucci
Aug 21, 2007·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Abdel Aziz M Shaheen, Robert P Myers
Jul 5, 2008·Digestive Diseases·George V Papatheodoridis
Nov 3, 2009·Journal of Clinical Gastroenterology·George V PapatheodoridisAthanasios J Archimandritis
Jan 13, 2016·World Journal of Gastroenterology : WJG·Pei-Pei SongWei Tang
Apr 3, 2014·Hepatitis Monthly·Simin Dokht ShoaeiEsmail Riahi

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