PMID: 6107858Oct 30, 1980Paper

Aspartate and glutamate as possible neurotransmitters of cells in layer 6 of the visual cortex

Nature
R W Baughman, C D Gilbert

Abstract

Earlier work has suggested that aspartate, glutamate and gamma-aminobutyric acid (GABA) act as transmitters in the cerebral cortex. There is reasonable evidence for the identity of the cell population responsible for GABA release but until now there has been little evidence concerning the sources for release of aspartate and glutamate. Here we have used two approaches to identify possible neurotransmitters used by cells in the visual cortex: measurement of the efflux of endogenous compounds in conditions of synaptic release and localization of these compounds to particular cell classes using neurotransmitter-specific histochemical techniques. Our results suggest that the acidic amino acids aspartate and glutamate may be cortical neurotransmitters, as shown by calcium-dependent release from endogenous stores and by uptake specific to pyramidal cells in layer 6 of the cortex. These substances may therefore have a role in the function of layer 6 cells, which are responsible for the recurrent projection from the cortex to the lateral geniculate nucleus and for the projection within the cortex from layer 6 to layer 4.

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Citations

Jan 1, 1989·Neurochemical Research·A D Sherman
Mar 1, 1987·Neuroscience and Behavioral Physiology·Z G Mamedov
Oct 1, 1982·European Journal of Drug Metabolism and Pharmacokinetics·G CampistronG Prat
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Apr 1, 1997·Progress in Neurobiology·M A Castro-Alamancos, B W Connors
Jul 1, 1997·Progress in Neurobiology·A Hashimoto, T Oka
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Dec 1, 1996·The European Journal of Neuroscience·C RivadullaJ Cudeiro
Aug 25, 2011·Electromagnetic Biology and Medicine·István BókkonAttila Erdöfi Szabó
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Oct 8, 1987·The Journal of Comparative Neurology·A J Weber, R E Kalil
Nov 1, 1981·Journal of Neurochemistry·M Sandberg, I Jacobson

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