PMID: 589462Dec 9, 1977

Aspartic acid and glutamic acid levels in the cochlear nucleus after auditory nerve lesion

Brain Research
R J Wenthold, R L Gulley

Abstract

Aspartic acid, glutamic acid and alanine were measured in the cochlear nucleus after lesioning the auditory nerve by cochlear ablation. Ultrastructural analysis of the cochlear nucleus showed that most primary auditory terminals were degenerating one day after cochlear ablation; the terminals were enlarged and the number of synaptic vesicles was reduced. Primary auditory terminals were virtually gone three days after cochlear ablation. Aspartic acid decreased after cochlear ablation in parallel with the morphological degeneration of the primary auditory terminals. The level of total aspartic acid in the cochlear nucleus had decreased more than 8% one day after cochlear ablation and more than 30% after two days, and remained at this level up to 28 days. Glutamic acid also decreased in the cochlear nucleus after cochlear ablation but not in parallel with the morphological degeneration of the primary auditory terminals. Following a slight increase one day after cochlear ablation, total glutamic acid decreased about 10% after two days and continued to decrease slowly through to day 28. Alanine dropped slowly after cochlear ablation and not in parallel with the degeneration of the primary terminals. Levels of other amino acids measu...Continue Reading

References

Jan 1, 1975·Annual Review of Pharmacology·F V DeFeudis
Jun 1, 1976·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·Donald A Godfrey, F M Matschinsky
Feb 1, 1976·Journal of Neurochemistry·G J BalcomJ L Meyerhoff
Nov 1, 1976·Journal of Neurochemistry·S K Fisher, W E Davies

Citations

Aug 13, 1986·Brain Research·R J WentholdR A Altschuler
Jan 1, 1987·Comparative Biochemistry and Physiology. A, Comparative Physiology·M J Drescher, D G Drescher
Jul 1, 1982·Hearing Research·J FexM H Parakkal
Feb 1, 1984·Hearing Research·D M CasparyC L Faingold
May 29, 2002·Hearing Research·Yingzhe LiRichard J Salvi
Oct 1, 1981·Proceedings of the National Academy of Sciences of the United States of America·R A AltschulerJ Fex
May 16, 2002·Experimental Neurology·J ZhangSteven J Potashner
Dec 3, 2013·Hearing Research·Donald A GodfreyMatthew A Godfrey
Jan 1, 1991·Acta Oto-laryngologica. Supplementum·C M Henley, M Igarashi
May 1, 1981·Acta Oto-laryngologica·R Klinke
Apr 4, 2015·Neuroscience·Donald A GodfreyK T Robinson
Dec 6, 2014·Frontiers in Neurology·Augustine C Lee, Donald A Godfrey
Jan 1, 1994·International Journal of Psychiatry in Medicine·B KalayamG K Tsuboyama
Aug 1, 1988·Journal of Neurochemistry·C Staatz-Benson, Steven J Potashner
Aug 15, 1978·The Journal of Comparative Neurology·R L GulleyT S Reese
Jan 27, 2004·Journal of Neuroscience Research·S M MulySteven J Potashner
Feb 6, 1999·The Journal of Comparative Neurology·L LuoR L Saint Marie
Jul 2, 2003·Journal of Neuroscience Research·Sanoj K Suneja, Steven J Potashner
Oct 1, 1983·Journal of Neurochemistry·Steven J Potashner
May 1, 1982·Journal of Neurochemistry·A Di LauroE Costa
Mar 30, 2005·Journal of Neuroscience Research·Sanoj K SunejaSteven J Potashner
Feb 1, 1985·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·J JarlstedtA Hamberger
Jan 1, 1991·European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·M BurianW Gstoettner
Sep 1, 1980·The Annals of Otology, Rhinology & Laryngology. Supplement·R J Wenthold

Related Concepts

Acoustic Nerve
Abufne
Aspartic Acid, Magnesium-Potassium (2:1:2) Salt
Auditory Pathway Structure
Cochlear Nerve
Glutamic Acids
Cavia porcellus
Nerve Endings
Synaptic Membranes
Synaptic Vesicles

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