Aspects of Gut Microbiota and Immune System Interactions in Infectious Diseases, Immunopathology, and Cancer

Frontiers in Immunology
Veronica LazarMariana Carmen Chifiriuc

Abstract

The microbiota consists of a dynamic multispecies community of bacteria, fungi, archaea, and protozoans, bringing to the host organism a dowry of cells and genes more numerous than its own. Among the different non-sterile cavities, the human gut harbors the most complex microbiota, with a strong impact on host homeostasis and immunostasis, being thus essential for maintaining the health condition. In this review, we outline the roles of gut microbiota in immunity, starting with the background information supporting the further presentation of the implications of gut microbiota dysbiosis in host susceptibility to infections, hypersensitivity reactions, autoimmunity, chronic inflammation, and cancer. The role of diet and antibiotics in the occurrence of dysbiosis and its pathological consequences, as well as the potential of probiotics to restore eubiosis is also discussed.

References

Dec 13, 1990·The New England Journal of Medicine·W C WillettF E Speizer
Feb 1, 1980·Journal of the National Cancer Institute·B R GoldinS L Gorbach
Jan 27, 1995·International Journal of Cancer. Journal International Du Cancer·A HagueC Paraskeva
Nov 18, 2000·International Journal of Molecular Medicine·M TatedaT Miyagi
Dec 6, 2000·Microbiology and Molecular Biology Reviews : MMBR·M E Davey, G A O'toole
Jan 17, 2002·Archives of Pharmacal Research·D H Kim, Y H Jin
Jan 28, 2003·Nature Immunology·Lora V HooperJeffrey I Gordon
Oct 9, 2003·Applied and Environmental Microbiology·Lilian SchoeferMichael Blaut
Nov 5, 2003·The Journal of Clinical Investigation·Morten Hentzer, Michael Givskov
Mar 20, 2004·The Journal of Infectious Diseases·Alessandro BartoloniGian Maria Rossolini
Dec 9, 2004·International Immunology·Kiyoshi Takeda, Shizuo Akira
Feb 16, 2005·Gut·G A W Rook, L R Brunet
Jun 15, 2005·Scandinavian Journal of Immunology·H Tlaskalova-HogenovaM Kverka
Dec 20, 2005·The Journal of Pathology·Jenny M Woof, Michael A Kerr
Feb 1, 2006·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·M K SalminenA Järvinen
Aug 26, 2006·Science·Heather L CashLora V Hooper
Sep 7, 2006·Nature Reviews. Drug Discovery·Jessica E BoldenRicky W Johnstone
Jan 9, 2007·Inflammatory Bowel Diseases·Julia-Stefanie FrickIngo B Autenrieth
Aug 19, 2007·Proceedings of the National Academy of Sciences of the United States of America·Daniel N FrankNorman R Pace
Nov 24, 2007·Journal of Medical Microbiology·Samuel J HooperMelanie J Wilson
Jan 17, 2008·Nature Reviews. Microbiology·David T Hughes, Vanessa Sperandio
May 21, 2008·Oncology Research·Michael BordonaroAlan C Sartorelli
May 30, 2008·Nature·Sarkis K MazmanianDennis L Kasper
Jun 27, 2008·Clinical and Vaccine Immunology : CVI·E MyllyluomaE Kankuri
Jun 28, 2008·The Journal of Antimicrobial Chemotherapy·Nahid KaramiAgnes E Wold
Jul 24, 2008·Annual Review of Biomedical Engineering·Arul Jayaraman, Thomas K Wood
Nov 26, 2008·Gastroenterology·Andrew S Neish
Mar 11, 2009·Frontiers in Bioscience (Landmark Edition)·Sam M MbulaiteyeEmad M El-Omar
Mar 11, 2009·Journal of Medical Microbiology·Johan DicksvedLars Engstrand
Apr 8, 2009·International Journal of Cancer. Journal International Du Cancer·Rachel R HuxleyMark Woodward
Aug 14, 2009·Journal of the Royal Society, Interface·Steve Atkinson, Paul Williams
Sep 15, 2009·International Journal of Food Microbiology·Saloomeh Moslehi-JenabianLene Jespersen

❮ Previous
Next ❯

Citations

Jan 15, 2019·Developmental Psychobiology·Bonnie E Brett, Carolina de Weerth
Nov 15, 2019·Current Opinion in Rheumatology·Lacey J FavazzoMichael J Zuscik
Nov 26, 2019·Journal of Animal Breeding and Genetics = Zeitschrift Für Tierzüchtung Und Züchtungsbiologie·Leticia P SanglardNick V L Serão
Dec 8, 2019·Protein Science : a Publication of the Protein Society·Monica Rosas-LemusKarla J F Satchell
Mar 3, 2020·Critical Reviews in Food Science and Nutrition·Jorge Armando Jiménez-AvalosMarisela González-Avila
Jan 30, 2020·Nutrients·Ignasi Azagra-BoronatMaria J Rodríguez-Lagunas
Apr 26, 2020·Current Opinion in Supportive and Palliative Care·Cyan L SylvesterAndrea M Stringer
May 20, 2020·The Journal of Physiology·Wenly RuanJames Versalovic
May 22, 2020·European Journal of Immunology·Virgil Schijns, Ed C Lavelle
Sep 8, 2019·Current Urology Reports·Karen M Wheeler, Michael A Liss
Feb 6, 2020·Frontiers in Medicine·Hamish C K AngusRoslyn A Kemp
Feb 25, 2020·Indian Journal of Microbiology·Vipin GuptaNirjara Singhvi
Jul 11, 2020·Nature Reviews. Gastroenterology & Hepatology·Giovanni CammarotaGiampaolo Tortora
Nov 9, 2018·Nutrients·Maria Elisabetta BaldassarreNicola Laforgia
Jun 26, 2020·Frontiers in Immunology·Patricia E ZerraSean R Stowell
Aug 25, 2020·Journal of Diabetes and Metabolic Disorders·Hanieh-Sadat EjtahedBagher Larijani
Apr 12, 2019·International Journal of Molecular Sciences·Valentina ZuccaroRaffaele Bruno
May 21, 2019·Clinical and Experimental Immunology·K M Maslowski
Nov 7, 2019·Journal of Clinical Medicine·Marilena DurazzoGabriella Gruden
Nov 26, 2019·Indian Journal of Microbiology·Lahari DasYogendra Singh
Feb 27, 2020·Future Oncology·Deniz Can GuvenSercan Aksoy
Jan 18, 2020·Scientific Reports·A HussoM Niku
Aug 6, 2020·International Journal of Molecular Sciences·Federica PerilloFederica Facciotti
May 13, 2020·Immune Network·Yoko M AmbrosiniHyun Jung Kim
Jul 9, 2020·International Journal of Environmental Research and Public Health·Carly Ray, Xue Ming
Sep 10, 2020·Frontiers in Immunology·Jefferson Elias-OliveiraDaniela Carlos
Mar 27, 2020·Clinical & Translational Immunology·Qibin LengFeng Wang
Apr 9, 2020·Frontiers in Immunology·Prathapan AyyappanNora E Sarvetnick
Oct 20, 2020·Frontiers in Cell and Developmental Biology·Tatiana V KirichenkoAlexander N Orekhov
Nov 10, 2020·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·Adrian Stencel
Nov 28, 2020·Microbial Cell Factories·Taha BaghbaniHamed Haddad Kashani
Jan 13, 2021·Obesity Reviews : an Official Journal of the International Association for the Study of Obesity·Rohit HariharanBarbora de Courten

❮ Previous
Next ❯

Methods Mentioned

BETA
cesarean section
biopsies
surgical resection

Related Concepts

Related Feeds

Antifungals (ASM)

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.

Autoimmune Diseases

Autoimmune diseases occur as a result of an attack by the immune system on the body’s own tissues resulting in damage and dysfunction. There are different types of autoimmune diseases, in which there is a complex and unknown interaction between genetics and the environment. Discover the latest research on autoimmune diseases here.

Allergies & Environmental Factors

Environmental factors are strongly associated with the prevalence of allergies and are an increasing health concern worldwide. Discover the latest research on Allergies and Environmental Factors here.

Allergy and Asthma

Allergy and asthma are inflammatory disorders that are triggered by the activation of an allergen-specific regulatory t cell. These t cells become activated when allergens are recognized by allergen-presenting cells. Here is the latest research on allergy and asthma.

Antifungals

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.

Related Papers

Cold Spring Harbor Perspectives in Medicine
Roberto Pacifici
Nature Reviews. Immunology
Iliyan D Iliev, Irina Leonardi
Wiener medizinische Wochenschrift
L Zawodsky
© 2022 Meta ULC. All rights reserved