PMID: 16538100Mar 16, 2006Paper

Aspects of hepatitis C virus infection relating to liver transplantation

European Journal of Gastroenterology & Hepatology
Bruno Roche, Didier Samuel

Abstract

End-stage liver disease caused by the hepatitis C virus (HCV) is a major indication for liver transplantation. HCV re-infection after transplantation is almost constant, and recent data confirm that it significantly impairs patient and graft survival. Factors that may influence disease severity and consequent progression of HCV graft injury remain unclear. Chronic HCV infection develops in 75-90% of patients, and 5-30% ultimately progress to cirrhosis within 5 years. Pre-transplantation antiviral treatment is not easily related to poor tolerance. Attempts to administer prophylactic post-transplantation antiviral treatment are under evaluation but are limited by the side-effects of antiviral drugs. Treatment of established graft lesions with interferon or ribavirin as single agents has been disappointing. Combination therapy gave promising results, with sustained virological response in 25-35% of patients, but indications, modality and duration of treatment should be assessed.

References

Oct 1, 1995·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·C FérayH Bismuth
Jan 1, 1995·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·P A SheinerC M Miller
Feb 1, 1995·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·P A Sheiner
Mar 28, 1996·The New England Journal of Medicine·E J GaneR Williams
Aug 1, 1997·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·T BizollonC Trepo
Mar 1, 1997·Liver Transplantation and Surgery : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·P A SheinerC M Miller
Apr 16, 1998·Clinical Transplantation·S FagiuoliN Zuhdi
May 15, 1998·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·E J GaneR Williams
Sep 10, 1998·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·M CharltonJ Hoofnagle
Sep 10, 1998·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·P A SheinerC M Miller
Dec 24, 1998·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·M PrietoJ Berenguer
Jan 12, 1999·Transplantation·H R Rosen, P Martin
Jan 27, 1999·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·H R RosenP Martin
Sep 26, 2000·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·M BerenguerJ Berenguer
Oct 26, 2000·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·R SreekumarM R Charlton
Oct 27, 2001·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·J AhmadA O Shakil
Oct 27, 2001·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·A B AlbertiG Pinzello
Mar 1, 2002·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Montserrat Garcia-RetortilloJuan Rodes
Apr 20, 2002·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Jeffrey S CrippinMichael R Charlton
Jun 27, 2002·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Marina BerenguerJoaquín Berenguer
Jun 29, 2002·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Kozhikode V Narayanan MenonMichael Charlton
Oct 4, 2002·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Gregory T Everson
Oct 24, 2002·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·A Obaid ShakilJorge Rakela
Nov 9, 2002·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Roberto J FirpiDavid R Nelson
Nov 9, 2002·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Ashok B JainJohn J Fung
Aug 28, 2003·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Roberto Troisi, Bernard de Hemptinne
Oct 31, 2003·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Gregory T Everson
Mar 9, 2004·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Mark W RussoRoshan Shrestha
Apr 27, 2004·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Guy W NeffEugene R Schiff

❮ Previous
Next ❯

Citations

Jul 7, 2009·The Medical Clinics of North America·Juan F Gallegos-Orozco, Hugo E Vargas
Feb 5, 2008·Clinics in Liver Disease·A Corbani, A K Burroughs
Dec 13, 2006·Transplant Immunology·Francisco Sánchez-BuenoPascual Parrilla
Nov 27, 2007·Liver International : Official Journal of the International Association for the Study of the Liver·Nyingi Kemmer, Guy W Neff
Nov 23, 2006·Transplantation Proceedings·Z HongM Dawood
Mar 22, 2014·Liver International : Official Journal of the International Association for the Study of the Liver·Harald FarnikMartin W Welker
Feb 22, 2011·Transplantation Proceedings·F R PonzianiS Fagiuoli

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antivirals (ASM)

Antivirals are medications that are used specifically for treating viral infections. Discover the latest research on antivirals here.

Antivirals

Antivirals are medications that are used specifically for treating viral infections. Discover the latest research on antivirals here.