PMID: 8950651Nov 1, 1996Paper

Aspects of the mechanics of lobed liposomes

Journal of Biomechanical Engineering
D C Pamplona, C R Calladine

Abstract

Hotani has studied, by means of dark-field light microscopy, morphological transformations which unilamellar liposomes undergo when their interior volume decreases steadily with time as a consequence of osmosis. In a previous paper, we made a theoretical study of the initial buckling of an originally spherical vesicle into the observed oblate spheroidal shape; and we argued that some in-plane shear elastic stiffness is required-in addition to the well-known flexural stiffness of the lipid bilayer-in order to explain the observed phenomena. In the present paper, we consider a later stage in the chain of morphological transitions observed by Hotani, when a series of cudgel-shaped lobes have sprung out of a previously axisymmetric, biconcave-shaped vesicle. Specifically, we compare the observed shapes of such lobes with half of a series of "peanut"-shaped vesicles that are an equilibrium conformation of an initially spherical liposome under reduced internal volume. We find that the shapes do not match well. On the other hand, the observed lobe forms do match satisfactorily portions of "undulating tube" shapes which evolve from a hypothetical cylindrical vesicle, according to some simple calculations. In view of this agreement, we ...Continue Reading

References

May 23, 1977·Journal of Mathematical Biology·J T Jenkins
Aug 1, 1976·Biophysical Journal·H J Deuling, W Helfrich
Apr 7, 1991·Journal of Theoretical Biology·T Sekimura, H Hotani
Oct 1, 1971·Proceedings of the National Academy of Sciences of the United States of America·R D Kornberg, H M McConnell
Sep 5, 1984·Journal of Molecular Biology·H Hotani
May 1, 1993·Journal of Biomechanical Engineering·D C Pamplona, C R Calladine
Dec 8, 1962·Nature·A D BANGHAMJ A LUCY

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Citations

Dec 31, 2002·Chemphyschem : a European Journal of Chemical Physics and Physical Chemistry·Kingo TakiguchiHirokazu Hotani
Jun 1, 2002·Journal of Biological Physics·F NomuraH Hotani
Oct 26, 1999·Journal of Biomechanical Engineering·T KosawadaG W Schmid-Schönbein
Oct 31, 2002·Journal of Biomechanical Engineering·C R Calladine, J A Greenwood
Dec 13, 2006·Journal of Biomechanical Engineering·Yong-Ping LiuAlvin C K Lai

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