PMID: 6408338Jun 1, 1983Paper

Aspects of the preoperative radiation therapy of patients with rectal and colonic cancer

Meditsinskaia radiologiia
G V GoldobenkoV V Prorokov

Abstract

The authors present some data on 288 patients with colonic and rectal cancer who were given preoperative radiotherapy, and on 145 patients with rectal cancer who underwent surgery only. In operable rectal cancer intensive irradiation at a single focal dose of 6.5 Gy and summary dose of 19.5 Gy (3 daily fractions), in operable colonic cancer 4 and 20 Gy (5 daily fractions respectively). The five-year survival rate attained during combined treatment of rectal cancer exceeded that after radical operations by 30%. Fractional-extended irradiation at a single focal dose of 4 Gy and summary dose of 40 Gy (every other day) in 44.6% of the patients permitted one to make locally disseminated rectal cancer resectable. Preoperative irradiation of locally disseminated rectal cancer with a preliminary synchronization of the tumor cell division cycle with 5-fluorouracil (a single focal dose of 6 Gy, summary dose of 36 Gy for irradiation twice a week) was well tolerated by the patients, and its effect on tumors was more noticeable as compared to radiotherapy only. Marked radiation reactions were absent in colonic cancer, radical operation (hemicolectomy) entailed no additional difficulties. Local recurrences were not noted in either of 10 pati...Continue Reading

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.