Aspects of the protein and the lipid composition of myelinoid Marchi-positive bodies from mammalian spinal cord.

Neurochemical Research
O CorneliusonP Fredman

Abstract

The fraction floating on 0.32 M sucrose was isolated from normal mammalian spinal cord and analyzed with regard to protein and lipid composition. Comparisons were made with the myelin fraction isolated from the same spinal cord. A close relationship between the two fractions was indicated by a similar protein banding on SDS-polyacrylamide gel electrophoresis. The relative amounts of various proteins however were different and some high molecular weight proteins appeared unique to the floating fraction. The phospho- and galactolipid patterns, as revealed by thin-layer chromatography, were similar in the floating and the myelin fractions. The proportion of hydrophobic lipids, such as sterols and isoprenyl derivatives, was higher in the floating fraction. Bands co-migrating with cholesterol esters were detected only in the floating fraction from guinea pigs. Marchi-positive material of possible paranodal origin is enriched in the floating fraction. The present findings of a biochemical composition of the floating fraction closely resembling that of myelin is in line with the view that myelin turnover includes a step of degradation localized to the paranodal regions.

References

May 1, 1978·Journal of Neurochemistry·R J McIntyreR O Brady
Aug 1, 1976·Journal of Neurochemistry·J A BenjaminsP Morell
Jul 21, 1987·Brain Research·O CorneliusonP Fredman
Sep 1, 1986·Neurochemical Research·P BürgisserT V Waehneldt
Jan 1, 1971·Acta Physiologica Scandinavica. Supplementum·C Hildebrand, S Skoglund
Apr 1, 1968·Journal of Neurology, Neurosurgery, and Psychiatry·S J Strich
Oct 1, 1973·Journal of Neurochemistry·W T Norton, S E Poduslo
Jan 1, 1973·Journal of Neurochemistry·A Bignami, L F Eng
Nov 1, 1971·Journal of Neurochemistry·S GreenfieldP Morell
Nov 15, 1981·Analytical Biochemistry·W WrayR Hancock
Jan 1, 1983·Methods in Enzymology·G L Peterson
Aug 1, 1983·Journal of Neurochemistry·F R BrownH W Moser
Jan 18, 1980·Biochimica Et Biophysica Acta·L Svennerholm, P Fredman
Jul 1, 1958·Clinica Chimica Acta; International Journal of Clinical Chemistry·N CRAWFORD
Nov 1, 1958·Neurology·F WOLFGRAM, A S ROSE
Jan 1, 1964·Journal of Neurochemistry·L A AUTILIOR D TERRY

❮ Previous
Next ❯

Citations

Jan 1, 1995·Acta Neuropathologica·Y HigashiK Suzuki
Dec 1, 1989·Neurochemical Research·H Persson, O Corneliuson
Mar 1, 1993·Progress in Neurobiology·C HildebrandC Bjartmar

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.