Aspergillus antigen induces robust Th2 cytokine production, inflammation, airway hyperreactivity and fibrosis in the absence of MCP-1 or CCR2

Respiratory Research
Laura L KothDavid J Erle

Abstract

Asthma is characterized by type 2 T-helper cell (Th2) inflammation, goblet cell hyperplasia, airway hyperreactivity, and airway fibrosis. Monocyte chemoattractant protein-1 (MCP-1 or CCL2) and its receptor, CCR2, have been shown to play important roles in the development of Th2 inflammation. CCR2-deficient mice have been found to have altered inflammatory and physiologic responses in some models of experimental allergic asthma, but the role of CCR2 in contributing to inflammation and airway hyperreactivity appears to vary considerably between models. Furthermore, MCP-1-deficient mice have not previously been studied in models of experimental allergic asthma. To test whether MCP-1 and CCR2 are each required for the development of experimental allergic asthma, we applied an Aspergillus antigen-induced model of Th2 cytokine-driven allergic asthma associated with airway fibrosis to mice deficient in either MCP-1 or CCR2. Previous studies with live Aspergillus conidia instilled into the lung revealed that MCP-1 and CCR2 play a role in anti-fungal responses; in contrast, we used a non-viable Aspergillus antigen preparation known to induce a robust eosinophilic inflammatory response. We found that wild-type C57BL/6 mice developed eosi...Continue Reading

References

Mar 1, 1992·The Journal of Clinical Investigation·R AlamJ A Grant
May 1, 1992·The Journal of Experimental Medicine·S C BischoffC A Dahinden
Jun 15, 1992·Proceedings of the National Academy of Sciences of the United States of America·H N AntoniadesD T Graves
Apr 1, 1989·The Journal of Experimental Medicine·T YoshimuraE J Leonard
Dec 1, 1994·European Journal of Immunology·P AllavenaA Mantovani
Feb 1, 1994·American Journal of Respiratory Cell and Molecular Biology·A R SousaR N Poston
Apr 26, 1994·Proceedings of the National Academy of Sciences of the United States of America·M W CarrT A Springer
Apr 1, 1996·American Journal of Respiratory and Critical Care Medicine·R AlamN Ida
Feb 1, 1997·American Journal of Respiratory and Critical Care Medicine·Y ZhangD B Lewis
Oct 29, 1997·Proceedings of the National Academy of Sciences of the United States of America·W A KuzielN Maeda
Dec 31, 1997·The Journal of Experimental Medicine·T KuriharaR Bravo
Jul 7, 1998·The Journal of Experimental Medicine·J A GonzaloJ C Gutierrez-Ramos
Feb 25, 1999·American Journal of Respiratory Cell and Molecular Biology·J A MacLeanG T De Sanctis
Feb 5, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·T R TraynorG B Huffnagle
Apr 7, 2000·The American Journal of Pathology·C M HogaboamS L Kunkel
Aug 18, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·K BleaseC M Hogaboam
Aug 29, 2000·Immunopharmacology·G B HuffnagleG B Toews
Nov 22, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·J A MacLeanA D Luster
Feb 13, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·K BleaseC M Hogaboam
Apr 6, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·Y KimC E Rose
Apr 18, 2001·International Archives of Allergy and Immunology·A B TonnelI Tillie-Leblond
Oct 10, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·B B MooreG B Toews
Dec 6, 2001·American Journal of Respiratory and Critical Care Medicine·Z ZhuJ A Elias
Mar 2, 2002·Immunology·Clare Lloyd
Mar 9, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Zhou ZhuJack A Elias
Apr 24, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Tim R TraynorGary B Huffnagle
May 11, 2002·American Journal of Physiology. Lung Cellular and Molecular Physiology·Ulrich A MausJürgen Lohmeyer
Mar 11, 2003·The Journal of Immunology : Official Journal of the American Association of Immunologists·Ulrich A MausJürgen Lohmeyer
Jun 19, 2003·The Journal of Clinical Investigation·Nives ZimmermannMarc E Rothenberg

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Citations

Nov 21, 2007·Medical Mycology·Javier CapillaDavid A Stevens
Aug 13, 2005·Respiratory Research·Dominik HartlSusanne Krauss-Etschmann
Jun 13, 2014·American Journal of Respiratory Cell and Molecular Biology·Tereza MartinuScott M Palmer
Jan 29, 2011·The Biochemical Journal·James E Pease
Nov 14, 2016·Medical Mycology·Takahiro Takazono, Donald C Sheppard
Aug 31, 2017·Nature Reviews. Immunology·Richard L GieseckThomas A Wynn
Dec 1, 2006·Journal of Leukocyte Biology·Paula K ShiremanLinda M McManus
Aug 7, 2008·Current Allergy and Asthma Reports·Lara E Kallal, Nicholas W Lukacs
Nov 19, 2011·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·E D GordonJ V Fahy
Feb 1, 2015·American Journal of Physiology. Lung Cellular and Molecular Physiology·Tereza TomankovaMingyao Liu
Feb 26, 2011·Expert Review of Respiratory Medicine·Yao ShenXiangdong Wang
Jun 12, 2013·American Journal of Physiology. Lung Cellular and Molecular Physiology·Bradley W BuczynskiMichael A O'Reilly
Apr 28, 2010·The Journal of Immunology : Official Journal of the American Association of Immunologists·Laura L KothPrescott G Woodruff
Jun 7, 2018·Frontiers in Immunology·Jie Dong, Qiang Ma

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Methods Mentioned

BETA
PCR
lavage
FCS
ELISA
bronchoalveolar lavage

Software Mentioned

R
STATA

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