Aspergillus brain abscess in a patient with acute myeloid leukaemia successfully treated with voriconazole

Clinical and Laboratory Haematology
F WandrooY Hasan

Abstract

Cerebral aspergillosis is associated with very high mortality in immunocompromised hosts. Conventional antifungal agents like amphotericin-B and itraconazole are almost ineffective in cerebral aspergillosis. Newer azoles have been shown to penetrate the blood, cerebrospinal fluid barrier and achieve effective fungicidal concentrations. These newer azoles may change the outlook of this fatal condition. We report here a patient with cerebral aspergillosis who was successfully treated with voriconazole.

References

Dec 1, 1992·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·P Francis, T J Walsh
Apr 1, 1991·The Journal of Antimicrobial Chemotherapy·N ColletteA Coune
Jul 28, 1983·The American Journal of Medicine·M R McGinnis
May 1, 1982·Neurology·M F BealR I Grossman
Jan 27, 1994·The New England Journal of Medicine·J A Como, W E Dismukes
Sep 1, 1996·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·D W Denning
Nov 26, 1997·Antimicrobial Agents and Chemotherapy·R HajduH Kropp
Mar 13, 1999·Journal of Clinical Microbiology·P E VerweijJ F Meis
Dec 1, 2000·The Pediatric Infectious Disease Journal
Jan 25, 2002·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·David W DenningHartmut Lode
Aug 9, 2002·The New England Journal of Medicine·Raoul HerbrechtUNKNOWN Invasive Fungal Infections Group of the European Organisation for Research and Treatment of Cancer and the Global Aspergillu
Sep 18, 2004·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·M S LionakisD P Kontoyiannis
Oct 9, 2004·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Kieren A MarrLawrence Corey

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