Aspergillus colonization and antifungal immunity in cystic fibrosis patients.

Medical Mycology
Adilia WarrisDarius Armstrong-James

Abstract

Cystic fibrosis (CF), caused by mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) gene, is the most common inherited life-limiting disease in North European people affecting 90,000 people worldwide. Progressive lung damage caused by recurrent infection and chronic airway inflammation is the major determinant of survival with a median age at death of 29 years. Approximately 60% of CF patients are infected with Aspergillus fumigatus, a ubiquitous environmental fungus, and its presence has been associated with accelerated lung function decline. Half of the patients infected with Aspergillus are <18 years of age. Yet time of acquisition of this fungus and determinants of CF-related Aspergillus disease severity and progression are not known. CFTR expression has been demonstrated in cells of the innate and adaptive immune system and has shown to be critical for normal function. Research delineating the role of CFTR-deficient phagocytes in Aspergillus persistence and infection in the CF lung, has only recently received attention. In this concise review we aim to present the current understanding with respect to when people with CF acquire infection with A. fumigatus and antifungal immune responses by CF immun...Continue Reading

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Citations

Feb 6, 2020·Journal of Fungi·Matthias EggerJuergen Prattes
Jun 18, 2019·Clinical Medicine Insights. Circulatory, Respiratory and Pulmonary Medicine·Emanuele DelfinoDaniele Roberto Giacobbe
Aug 15, 2020·Frontiers in Cellular and Infection Microbiology·Alexander J CurrieAdilia Warris
Dec 3, 2020·Frontiers in Cellular and Infection Microbiology·Otávio Guilherme Gonçalves de AlmeidaMarcia Regina von Zeska Kress
Feb 16, 2021·Frontiers in Cellular and Infection Microbiology·Claudia GrehnCarsten Schwarz
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Apr 5, 2021·Mycopathologia·Amelia BercussonAnand Shah

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Aspergillosis

Aspergillosis is the name given to a wide variety of diseases caused by infection by fungi of the genus Aspergillus. Aspergillosis occurs in chronic or acute forms which are clinically very distinct. Most cases of acute aspergillosis occur in patients with severely compromised immune systems. Chronic colonization or infection can cause complications in people with underlying respiratory illnesses. Discover the latest research on aspergillosis here.

Aspergillosis (ASM)

Aspergillosis is the name given to a wide variety of diseases caused by infection by fungi of the genus Aspergillus. Aspergillosis occurs in chronic or acute forms which are clinically very distinct. Most cases of acute aspergillosis occur in patients with severely compromised immune systems. Chronic colonization or infection can cause complications in people with underlying respiratory illnesses. Discover the latest research on aspergillosis here.