PMID: 8586122Oct 1, 1995Paper

Aspergillus culture filtrates and sputum sols from patients with pulmonary aspergillosis cause damage to human respiratory ciliated epithelium in vitro

The European Respiratory Journal
R AmitaniF Kuze

Abstract

Aspergillus species frequently colonize lower respiratory tracts and lungs with localized underlying conditions (healed tuberculous cavity, cystic fibrosis, bronchiectasis, etc.) even in subjects without systemic predisposing factors. We investigated the in vitro effects of culture filtrates of Aspergillus species and sputum sols from patients with pulmonary aspergillosis on ciliary beat frequency (CBF) and epithelial integrity of human respiratory ciliated epithelium. Culture filtrates of 25 clinically isolated fungi (16 Aspergillus fumigatus, three Aspergillus niger, one Aspergillus flavus, three Candida albicans, and two Cryptococcus neoformans) were obtained by culturing the fungi in Medium-199 at 37 degrees C for 7 days, and five sputum sols were obtained from patients with pulmonary aspergillosis infected by A. fumigatus. During 6 h experiments using a photometric technique, 14 out of 16 A. fumigatus culture filtrates caused progressive and significant reduction in CBF associated with marked epithelial disruption, whilst the culture filtrates of A. niger and A. flavus caused minor epithelial damage without slowing of CBF, and Medium-199 alone (Control) showed neither epithelial damage nor slowing of CBF. All of the sputum...Continue Reading

Citations

Apr 23, 2009·Medical Mycology·David L Goldman, Gary B Huffnagle
Jul 15, 2009·Clinical Microbiology Reviews·Taylor R T Dagenais, Nancy P Keller
Mar 6, 2010·Journal of Medical Microbiology·John P FallonKevin Kavanagh
Aug 15, 2002·European Journal of Pediatrics·Kiyotaka SuzukiHideki Iwata
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Dec 24, 2018·Journal of Veterinary Internal Medicine·Julie DauvillierEmmanuelle van Erck-Westergren
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