Aspergillus fabM encodes an essential product that is related to poly(A)-binding proteins and activates development when overexpressed.

Genetics
J Marhoul, T H Adams

Abstract

Overexpression of several different Aspergillus nidulans developmental regulatory genes has been shown to cause inappropriate developmental activation and growth inhibition. We previously exploited this observation that induced development caused growth inhibition in designing a screen to identify other genes that could activate development when overexpressed. We identified 16 mutants in which induced expression of different random genomic DNA sequences caused growth inhibition, accumulation of mRNA corresponding to the brlA developmental regulatory locus, and in several cases sporulation. This phenotype was designated FAB for Forced expression Activation of brlA and the genes were called fabA through fabP. Here we describe one of these genes, fabM, which is predicted to encode a poly(A)-binding protein (PABP) that is constitutively expressed and is essential for viability. While it is unclear why overexpression of the fabM caused sporulation, we showed that this activity required other known early developmental regulators including brlA beta, flbA, flbB, flbC, and fluG. We propose that fabM is an example of a gene that is not only required for growth, but also has specific functions early in development that assist, developmen...Continue Reading

Citations

Apr 8, 1998·Microbiology and Molecular Biology Reviews : MMBR·T H AdamsJ H Yu
May 21, 1998·Fungal Genetics and Biology : FG & B·M S Sachs
Oct 29, 1997·Molecular and Cellular Biology·J C Torres-Guzmán, A Domínguez
Mar 23, 2021·Journal of Microbiology and Biotechnology·Sung-Hun SonHee-Soo Park

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