Aspergillus fumigatus LaeA-mediated phagocytosis is associated with a decreased hydrophobin layer.

Infection and Immunity
Taylor R T DagenaisNancy P Keller

Abstract

Aspergillus fumigatus is the causal agent of the life-threatening disease invasive aspergillosis. A. fumigatus laeA deletants, aberrant in toxin biosynthesis and spore development, are decreased in virulence. Among other characteristics, the decreased virulence is associated with increased spore susceptibility to macrophage phagocytosis. Three characteristics, cell wall microbe-associated molecular patterns (MAMPs), secreted metabolites, and rodlet content, thought to be important in macrophage-Aspergillus spore interactions were examined. Flow cytometry analysis of wild-type and DeltalaeA spores did not reveal any differences in surface-accessible MAMPs, including beta-(1,3)-glucan, alpha-mannose, chitin, and other carbohydrate ligands. Blocking experiments with laminarin and mannan supported the conclusion that differences in cell wall carbohydrates were not responsible for enhanced DeltalaeA spore phagocytosis. Aspergillus spores have been reported to secrete metabolites affecting phagocytosis. Neither spent culture exchange, transwell, nor coincubation internalization experiments supported a role for secreted metabolites in the differential uptake of wild-type and DeltalaeA spores. However, sonication assays implicated a ro...Continue Reading

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Citations

Jul 1, 2011·The Journal of Microbiology·Wenbing Yin, Nancy P Keller
Jun 15, 2011·Current Opinion in Infectious Diseases·Robert A CramerTobias M Hohl
Jun 14, 2012·PLoS Pathogens·Jagadeesh BayryJean-Paul Latgé
Apr 26, 2011·Annual Review of Phytopathology·Saori Amaike, Nancy P Keller
May 9, 2012·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·W-K SunY Shi
Apr 7, 2011·Applied Microbiology and Biotechnology·Mona Højgaard PedersenIb Søndergaard
Jul 16, 2010·Current Opinion in Microbiology·Axel A BrakhageJudith Behnsen
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Nov 8, 2016·Fungal Genetics and Biology : FG & B·Pranav Chettri, Rosie E Bradshaw
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Feb 18, 2018·Brazilian Journal of Microbiology : [publication of the Brazilian Society for Microbiology]·Ildnay de Souza Lima BrandãoOliane Maria Correia Magalhães
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Aug 17, 2021·Microbiological Research·Catalina Landeta-SalgadoMaría Elena Lienqueo

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