PMID: 8962148Dec 10, 1996Paper

Aspergillus has distinct fatty acid synthases for primary and secondary metabolism

Proceedings of the National Academy of Sciences of the United States of America
D W BrownN P Keller

Abstract

Aspergillus nidulans contains two functionally distinct fatty acid synthases (FASs): one required for primary fatty acid metabolism (FAS) and the other required for secondary metabolism (sFAS). FAS mutants require long-chain fatty acids for growth, whereas sFAS mutants grow normally but cannot synthesize sterigmatocystin (ST), a carcinogenic secondary metabolite structurally and biosynthetically related to aflatoxin. sFAS mutants regain the ability to synthesize ST when provided with hexanoic acid, supporting the model that the ST polyketide synthase uses this short-chain fatty acid as a starter unit. The characterization of both the polyketide synthase and FAS may provide novel means for modifying secondary metabolites.

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Citations

Mar 19, 2013·Applied Microbiology and Biotechnology·Bijinu BalakrishnanHyung-Jin Kwon
Mar 31, 2004·Fungal Genetics and Biology : FG & B·Richard A WilsonNancy P Keller
Aug 25, 2010·Quarterly Reviews of Biophysics·Timm MaierNenad Ban
Mar 1, 2011·Journal of the American Chemical Society·James F SanchezBerl R Oakley
Apr 25, 2013·Journal of the American Chemical Society·Kan'ichiro IshiuchiKenji Watanabe
May 19, 2009·Nature Chemical Biology·Jin Woo BokNancy P Keller
Nov 17, 2010·Nature Reviews. Microbiology·Jason M Crawford, Craig A Townsend
Apr 16, 2008·Biological Reviews of the Cambridge Philosophical Society·Florian Pankewitz, Monika Hilker
Aug 26, 2004·Antimicrobial Agents and Chemotherapy·Marcia A S GraminhaNilce M Martinez-Rossi
May 24, 2011·Applied and Environmental Microbiology·André SchusterMonika Schmoll
Jan 5, 2000·Applied and Environmental Microbiology·N P KellerC A Townsend
Mar 10, 2004·Applied and Environmental Microbiology·Jiujiang YuJoan W Bennett
Dec 14, 2004·Eukaryotic Cell·Dimitrios I TsitsigiannisNancy P Keller
Mar 10, 2004·Microbiology and Molecular Biology Reviews : MMBR·Katherine A BorkovichRobert Pratt
Sep 9, 2004·Microbiology and Molecular Biology Reviews : MMBR·Eckhart Schweizer, Jörg Hofmann
Mar 12, 2004·Annual Review of Phytopathology·G A Payne, M P Brown
Oct 31, 2006·Proceedings of the National Academy of Sciences of the United States of America·Jason M CrawfordCraig A Townsend
Aug 7, 2002·Proceedings of the National Academy of Sciences of the United States of America·J P BerryR E Gawley
Apr 26, 2011·Annual Review of Phytopathology·Saori Amaike, Nancy P Keller
Sep 2, 2005·Molecular Plant-microbe Interactions : MPMI·Lori A Maggio-HallNancy P Keller
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Feb 19, 2008·Mycological Research·Imke SchmittH Thorsten Lumbsch
Jun 25, 2014·Proceedings of the National Academy of Sciences of the United States of America·Robert RileyIgor V Grigoriev
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Nov 17, 2012·Microbiology·Melinda SzilágyiTamás Emri
Jan 8, 2013·Journal of Molecular Biology·Daniel BoehringerMarc Leibundgut
May 13, 2014·Chemistry & Biology·Christoph ZaehleMatthias Brock
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Feb 2, 2017·Frontiers in Microbiology·Pradeep KumarSang G Kang

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