Aspergillus-Pseudomonas interaction, relevant to competition in airways

Medical Mycology
Gabriele SassDavid A Stevens

Abstract

In airways of immunocompromised patients and individuals with cystic fibrosis, Pseudomonas aeruginosa and Aspergillus fumigatus are the most common opportunistic bacterial and fungal pathogens. Both pathogens form biofilms and cause acute and chronic illnesses. Previous studies revealed that P. aeruginosa is able to inhibit A. fumigatus biofilms in vitro. While numerous P. aeruginosa molecules have been shown to affect A. fumigatus, there never has been a systematic approach to define the principal causative agent. We studied 24 P. aeruginosa mutants, with deletions in genes important for virulence, iron acquisition, or quorum sensing, for their ability to interfere with A. fumigatus biofilms. Cells, planktonic or biofilm culture filtrates of four P. aeruginosa mutants, pvdD-pchE-, pvdD-, lasR-rhlR-, and lasR-, inhibited A. fumigatus biofilm metabolism or planktonic A. fumigatus growth significantly less than P. aeruginosa wild type. The common defect of these four mutants was a lack in the production of the P. aeruginosa siderophore pyoverdine. Pure pyoverdine affected A. fumigatus biofilm metabolism, and restored inhibition by the above mutants. In lungs from cystic fibrosis patients, pyoverdine production and antifungal acti...Continue Reading

References

Oct 1, 1969·Journal of General Microbiology·A Mangan
Oct 26, 1999·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·S HäusslerI Steinmetz
Nov 24, 1999·Journal of Clinical Pathology·J R KerrR Wilson
Oct 27, 2004·The Journal of Experimental Medicine·Markus SchrettlHubertus Haas
Jul 15, 2006·Chest·David ShoseyovEitan Kerem
Jul 29, 2006·Environmental Microbiology·Florian BredenbruchSusanne Häussler
Oct 14, 2006·Genome Biology·Daniel G LeeFrederick M Ausubel
Aug 30, 2008·Molecular Microbiology·Markus SchrettlHubertus Haas
Oct 15, 2010·International Journal of Medical Microbiology : IJMM·Michael Hogardt, Jürgen Heesemann
Apr 1, 2011·Environmental Microbiology·Sophie de Bentzmann, Patrick Plésiat
May 24, 2011·Seminars in Oncology·Jørn Herrstedt, Declan Walsh
Jun 7, 2011·Biometals : an International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine·Lois W MartinIain L Lamont
Aug 8, 2012·Proceedings of the National Academy of Sciences of the United States of America·Wilna J MoreePieter C Dorrestein
Nov 14, 2012·Nature Reviews. Microbiology·Anders FolkessonSøren Molin
Dec 3, 2013·Frontiers in Cellular and Infection Microbiology·Pierre Cornelis, Jozef Dingemans
Dec 3, 2014·Journal of Cystic Fibrosis : Official Journal of the European Cystic Fibrosis Society·Raquel SabinoDavid A Stevens
Mar 21, 2015·Biometals : an International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine·Angela T Nguyen, Amanda G Oglesby-Sherrouse
Apr 29, 2015·Journal of Bacteriology·Angela T NguyenAmanda G Oglesby-Sherrouse
Aug 5, 2015·Antimicrobial Agents and Chemotherapy·Hasan NazikDavid A Stevens
Nov 1, 2018·Current Opinion in Infectious Diseases·Efthymia I MatthaiouJoe L Hsu

❮ Previous
Next ❯

Citations

Jul 15, 2020·Annual Review of Microbiology·Kirstin Scherlach, Christian Hertweck
Jul 30, 2020·Journal of Fungi·Hasan NazikDavid A Stevens
Nov 20, 2019·Journal of Clinical Medicine·Yen-Ting LuTzu-Hao Chang
Oct 13, 2020·Current Clinical Microbiology Reports·Krystal Y Chung, Jessica C S Brown
Jan 15, 2021·Brazilian Journal of Microbiology : [publication of the Brazilian Society for Microbiology]·Andressa de Jesus MarquesLivia Cristina Liporagi-Lopes
Oct 19, 2019·Microorganisms·Filomena NogueiraThomas Lion
Nov 20, 2020·European Respiratory Review : an Official Journal of the European Respiratory Society·Karen KeownDamian G Downey
Mar 20, 2021·Expert Review of Respiratory Medicine·Celine Vidaillac, Sanjay H Chotirmall
Apr 4, 2021·Antibiotics·Aidan K Curran, David L Hava

❮ Previous
Next ❯

Related Concepts

Related Feeds

Aspergillosis

Aspergillosis is the name given to a wide variety of diseases caused by infection by fungi of the genus Aspergillus. Aspergillosis occurs in chronic or acute forms which are clinically very distinct. Most cases of acute aspergillosis occur in patients with severely compromised immune systems. Chronic colonization or infection can cause complications in people with underlying respiratory illnesses. Discover the latest research on aspergillosis here.

Biofilm & Infectious Disease

Biofilm formation is a key virulence factor for a wide range of microorganisms that cause chronic infections.Here is the latest research on biofilm and infectious diseases.

Biofilms

Biofilms are adherent bacterial communities embedded in a polymer matrix and can cause persistent human infections that are highly resistant to antibiotics. Discover the latest research on Biofilms here.

Aspergillosis (ASM)

Aspergillosis is the name given to a wide variety of diseases caused by infection by fungi of the genus Aspergillus. Aspergillosis occurs in chronic or acute forms which are clinically very distinct. Most cases of acute aspergillosis occur in patients with severely compromised immune systems. Chronic colonization or infection can cause complications in people with underlying respiratory illnesses. Discover the latest research on aspergillosis here.