Aspergillus terreus Causing Probable Invasive Aspergillosis in a Patient with Cystic Fibrosis

Mycopathologia
Shreya SinghArunaloke Chakrabarti

Abstract

Aspergillus terreus may colonize the airways of patients with cystic fibrosis (CF). Whether this merits antifungal treatment is still unclear due to heterogeneous reports regarding its pathogenic potential. Although allergic manifestations are documented, invasive aspergillosis (IA) caused by A. terreus has not been described. We present here one case of probable IA caused by A. terreus, highlighting its role as an emerging agent of IA in CF patients. Voriconazole was effective, and the patient was healthy after 12 weeks of treatment. Serial determination of serum galactomannan level and periodic cultures from respiratory specimens may help in monitoring CF patients by identifying such pathogens. Further studies on the fungal species colonizing the CF airways are warranted, especially in India. This case report suggests A. terreus as a potential agent of IA which should not be ignored, particularly in this patient group.

References

Oct 18, 2002·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Laura ChowDennis Kunimoto
Sep 17, 2003·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·David A StevensUNKNOWN Participants in the Cystic Fibrosis Foundation Consensus Conference
Jul 22, 2008·The Journal of Pediatrics·Philip M FarrellUNKNOWN Cystic Fibrosis Foundation
Aug 20, 2010·Medical Mycology·Arunaloke ChakrabartiM R Shivaprakash
Sep 9, 2010·The Pediatric Infectious Disease Journal·Joanna MassamValerie Waters
Apr 7, 2012·Nature Medicine·Taylor Sitarik Cohen, Alice Prince
Apr 25, 2012·Medical Mycology·Thomas A WarrenValerie Waters
Aug 10, 2013·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·A RougeronC H W Klaassen
Sep 26, 2013·Current Opinion in Pulmonary Medicine·Peter G MiddletonWieland Meyer
Nov 20, 2013·BMJ Case Reports·Ricardo Alberto MosqueraCindy K Jon
Jul 25, 2014·Medical Mycology·Maria NoniChryssa Tzoumaka-Bakoula
Jul 17, 2015·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·V N Maturu, R Agarwal
Aug 20, 2015·Medical Mycology Case Reports·Katie DunnePhilip Murphy
Feb 18, 2016·Respiratory Investigation·Christian Geltner, Cornelia Lass-Flörl
Oct 6, 2016·Infection and Drug Resistance·Pierre-Régis BurgelClémence Martin

❮ Previous
Next ❯

Citations

Jul 1, 2021·Clinical Microbiology Reviews·Cornelia Lass-FlörlMatthias Brock

❮ Previous
Next ❯

Methods Mentioned

BETA
X
ray

Related Concepts

Related Feeds

Antifungals (ASM)

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.

Aspergillosis

Aspergillosis is the name given to a wide variety of diseases caused by infection by fungi of the genus Aspergillus. Aspergillosis occurs in chronic or acute forms which are clinically very distinct. Most cases of acute aspergillosis occur in patients with severely compromised immune systems. Chronic colonization or infection can cause complications in people with underlying respiratory illnesses. Discover the latest research on aspergillosis here.

Aspergillosis (ASM)

Aspergillosis is the name given to a wide variety of diseases caused by infection by fungi of the genus Aspergillus. Aspergillosis occurs in chronic or acute forms which are clinically very distinct. Most cases of acute aspergillosis occur in patients with severely compromised immune systems. Chronic colonization or infection can cause complications in people with underlying respiratory illnesses. Discover the latest research on aspergillosis here.

Antifungals

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.