Aspergoterpenins A⁻D: Four New Antimicrobial Bisabolane Sesquiterpenoid Derivatives from an Endophytic Fungus Aspergillus versicolor

Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry
Zhi-yong GuoPeter Proksch

Abstract

Aspergoterpenins A⁻D (1⁻4), four new bisabolane sesquiterpenoid derivatives, were obtained from the endophytic fungus, Aspergillus versicolor, together with eight known compounds (5⁻12), and their structures were elucidated by a comprehensive analysis of their NMR (Nuclear Magnetic Resonance), MS (Mass Spectrum) and CD (Circular Dichroism) spectra. Aspergoterpenin A (1) was the first example with a characteristic ketal bridged-ring part in the degraded natural bisabolane-type sesquiterpene structures. The compounds 1⁻12 displayed no significant activities against four cancer cell lines (A549, Caski, HepG2 and MCF-7). Further, the antimicrobial activities to Erwinia carotovora sub sp. Carotovora were evaluated, and the results showed that compounds 1⁻12 displayed antimicrobial activities with MIC values ranging from 15.2 to 85.2 μg/mL.

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Citations

Jun 12, 2020·Natural Product Research·Yanqing YeMiao Dong
Oct 22, 2019·Mycology·Abdulkawi Ali Al-Fakih, Wael Qasem Abdulgabbar Almaqtri
Aug 7, 2021·Journal of Fungi·Humberto E OrtegaLuis Cubilla-Rios
Aug 23, 2021·Chinese Journal of Natural Medicines·Jie WangHou-Wen Lin
Nov 21, 2021·BMC Microbiology·Saeed Ullah KhattakSaima Ikram

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Methods Mentioned

BETA
NMR
nuclear magnetic resonance
column chromatography
Assay

Software Mentioned

Gaussian09
conflex
SpecDis1

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An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.