Aspidosperma pyrifolium Mart: neuroprotective, antioxidant and anti-inflammatory effects in a Parkinson's disease model in rats

The Journal of Pharmacy and Pharmacology
Dayane Pessoa de AraújoGlauce Socorro de Barros Viana

Abstract

Aspidosperma species are used for several diseases, especially for malaria in Brazil. Although the genus is object of pharmacological studies, almost none are found on Aspidosperma pyrifolium. We investigate neuroprotective, antioxidant and anti-inflammatory properties of the APSE-Aq fraction (benzoic acid glycosylated derivative) on Parkinson's disease model. Male Wistar rats were subjected to a 6-hydroxydopamine injection into the right striatum and treated or not with APSE-Aq (100 or 200 mg/kg, p.o.). The sham-operated group was injected with saline. Two weeks later, animals were subjected to behavioural, neurochemical and immunohistochemical evaluation. The data were analysed by ANOVA and Tukey test. The APSE-Aq-treated group shows a partial recovery of behavioural changes as compared with the untreated-6-hydroxydopamine group. A partial recovery was also observed in nitrite contents and lipid peroxidation. APSE-Aq treatments significantly reversed decreases in striatal dopamine and metabolites in the untreated 6-hydroxydopamine group. Immunostainings for markers as tyrosine hydroxylase and dopamine transporter decreased in the untreated 6-hydroxydopamine group and values recovered after APSE-Aq treatments. Similar data wer...Continue Reading

References

Apr 1, 1992·Journal of Ethnopharmacology·M G BrandãoA U Krettli
Jan 1, 1990·Methods in Enzymology·H H Draper, M Hadley
Oct 1, 1982·Analytical Biochemistry·L C GreenS R Tannenbaum
Sep 29, 1998·Journal of Neurochemistry·N AubinC Carter
Dec 1, 2000·Zeitschrift Für Naturforschung. C, a Journal of Biosciences·A F Oliveira, A Salatino
Nov 6, 2001·Journal of Ethnopharmacology·B WenigerR Anton
May 9, 2002·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·A C Mitaine-OfferM Zèches-Hanrot
Apr 1, 2003·Annals of Neurology·Peter Jenner
Jan 6, 2004·Journal of Neuroscience Research·J P De La CruzF Sánchez de la Cuesta
Jul 27, 2004·Memórias do Instituto Oswaldo Cruz·Izabel Cristina Piloto FerreiraArildo José Braz de Oliveira
Apr 12, 2005·Annual Review of Pharmacology and Toxicology·De-Maw ChuangVladimir V Senatorov
Mar 1, 2006·Proceedings of the National Academy of Sciences of the United States of America·Makoto R HaraSolomon H Snyder
Apr 25, 2006·Cellular and Molecular Neurobiology·Makoto R Hara, Solomon H Snyder
Nov 14, 2006·Journal of Ethnopharmacology·M L de MesquitaL S Espindola
Dec 5, 2006·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·J C A TanakaA J B de Oliveira
Jan 27, 2007·Planta medica·A C MitaineM Zèches-Hanrot
Apr 24, 2007·Neurotoxicity Research·Nicola SimolaAnna R Carta
Dec 17, 2008·Annals of the New York Academy of Sciences·Chun ZhouSerge Przedborski
Jan 24, 2009·Biochimica Et Biophysica Acta·Anthony H K Tsang, Kenny K K Chung
Apr 30, 2009·Annual Review of Phytopathology·A Corina VlotDaniel F Klessig
Apr 3, 2010·Journal of Neuroscience Methods·Hiromi ShiotsukiNobutaka Hattori
May 12, 2010·Cold Spring Harbor Perspectives in Biology·Toby Lawrence
Apr 14, 2011·British Journal of Pharmacology·Susan Duty, Peter Jenner
Aug 5, 2011·Zeitschrift Für Naturforschung. C, a Journal of Biosciences·Matías ReinaAzucena González-Coloma
Feb 4, 2012·The Arabidopsis Book·D'Maris Amick DempseyDaniel F Klessig
Feb 14, 2012·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·Ananda de Castro CunhaArildo José Braz de Oliveira
Jul 21, 2012·Advances in Protein Chemistry and Structural Biology·Kemal Ugur TufekciKursad Genc
Dec 5, 2012·Anais Da Academia Brasileira De Ciências·Maria Fâni DolabelaAlaide B Oliveira
Jun 20, 2013·TheScientificWorldJournal·Anansa Bezerra de AquinoJoão Xavier de Araújo-Júnior
Nov 21, 2013·Journal of Parkinson's Disease·Vera DiasM Maral Mouradian
Apr 16, 2014·Malaria Journal·Talita P C ChierritoAntoniana U Krettli
Jul 8, 2014·Oxidative Medicine and Cellular Longevity·Antonio AyalaSandro Argüelles
Jan 30, 2015·Frontiers in Plant Science·Murli ManoharDaniel F Klessig
Oct 16, 2015·Translational Neurodegeneration·Qinqin WangJiawei Zhou
Jan 15, 2016·Journal of Neuroscience Research·Anna-Maija PenttinenMikko Airavaara
Jun 16, 2016·Frontiers in Immunology·Daniel F KlessigHyong Woo Choi

❮ Previous
Next ❯

Citations

Oct 27, 2020·Oxidative Medicine and Cellular Longevity·Sandro PercárioMaria Fani Dolabela
Aug 3, 2021·Frontiers in Cell and Developmental Biology·Longping YaoGuohui Lu

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antimalarial Agents (ASM)

Antimalarial agents, also known as antimalarials, are designed to prevent or cure malaria. Discover the latest research on antimalarial agents here.

Antimalarial Agents

Antimalarial agents, also known as antimalarials, are designed to prevent or cure malaria. Discover the latest research on antimalarial agents here.