Aspiration and development of subglottic stenosis in patients with Wegener's granulomatosis

The Journal of Laryngology and Otology
A C ChurchP Sivasothy

Abstract

In patients with Wegener's granulomatosis, subglottic stenosis can develop due to active disease; however, some patients develop subglottic stenosis with no clear evidence of airway inflammation. In some cases of idiopathic subglottic stenosis, an association with gastroesophageal reflux disease has been found. Our study assessed the potential role of gastroesophageal reflux as an aetiological factor in the development of subglottic stenosis in patients with Wegener's granulomatosis. We assessed evidence of active reflux disease, using 24-hour pH monitoring and assessment of bile salts in bronchoalveolar lavage fluid. Ten Wegener's granulomatosis patients with subglottic stenosis underwent 24-hour pH monitoring and bronchoscopy and lavage of the right middle lobe. A similar number of control patients were included. There was no statistically significant difference in the occurrence of bronchoalveolar bile salts in patients with subglottic stenosis (n = 2) versus control patients (zero) (p = 0.457). There was good correlation between the detection of reflux by 24-hour pH monitoring and the detection of bronchoalveolar bile salts (kappa = 0.769). In this small study of patients with Wegener's granulomatosis, there was no evidence...Continue Reading

References

Feb 1, 1995·American Journal of Respiratory and Critical Care Medicine·T E DaumR A DeRemee
Jul 24, 2001·The Annals of Otology, Rhinology, and Laryngology·N C MaronianA Hillel
Aug 5, 2003·The Laryngoscope·Michael B GluthJan L Kasperbauer
May 4, 2005·The Journal of Thoracic and Cardiovascular Surgery·Frank D'OvidioShaf Keshavjee
Aug 8, 2006·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·F D'OvidioS Keshavjee

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Citations

May 9, 2013·Gastroenterology Research and Practice·Ossur Ingi EmilssonIsleifur Olafsson
Nov 8, 2012·European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·Haralampos GouverisWolf Mann

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