PMID: 7381740May 1, 1980

Aspirin--a national survey II: Determination of salicylic acid in bulk aspirin and aspirin formulations by high-pressure liquid chromatography using a fluorescence detector

Journal of Pharmaceutical Sciences
R D Kirchhoefer, W E Juhl


A quantitative high-pressure liquid chromatographic method, using a reversed-phase column coupled to a fluorescence detector, was developed to determine salicylic acid in bulk aspirin and plain and buffered aspirin tablets. The aspirin was dissolved, filtered, and injected into the chromatograph; the fluorescence of the salicylic acid was measured at approximately 425 nm. Excipients and impurities did not interfere, and recoveries of 100% were obtained. The method was used to analyze 84 aspirin samples.


Jun 22, 1984·Pharmaceutisch Weekblad. Scientific Edition·A M WahbiM A Korany
Jan 1, 1984·Journal of Pharmaceutical and Biomedical Analysis·S A Winfield, A T Williams
Jul 1, 1982·The Journal of Pharmacy and Pharmacology·P MazzeoF Segnalini

Related Concepts

High Pressure Liquid Chromatography Procedure
Salicylic Acids

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