Aspirin--relieved asthma

Medical Hypotheses
P Garin, A Frans

Abstract

It is widely known that there might occur three different responses to the administration of ASA or NSAID to patients with bronchial asthma-bronchoconstriction, bronchodilatation or lack of bronchopulmonary action. Nevertheless, the beneficial effect of SAID has been confirmed in patients who are both nonallergic and cortico-dependent asthmatics. Our hypothesis is that in these specific cases the arachidonic acid metabolism is diverted towards cyclo-oxygenase products and that this metabolic diversion leads to an increased production of bronchoconstriction prostaglandins. The administration of NSAID inhibits the cyclo-oxygenase suppressing the enhanced basal production of these bronchoconstrictors and relieving the bronchospasm. The suspected abnormality in arachidonic acid metabolism would be restricted to the respiratory system.

References

Apr 1, 1978·Annals of Internal Medicine·D KordanskyR R Rosenthal
Oct 1, 1978·Thorax·A SzczeklikE Nizankowska
Mar 1, 1986·New England and Regional Allergy Proceedings·R P NelsonR F Lockey
Jan 1, 1984·Respiration; International Review of Thoracic Diseases·O RestaV Picca

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