PMID: 332184Jul 1, 1977Paper

Aspirin and delayed type hypersensitivity

Arthritis and Rheumatism
M W DuncanJ T Sharp

Abstract

The effects of aspirin on delayed hypersensitivity were assessed in 40 healthy subjects who were randomly assigned to two equal groups. In a double-blind format, the individuals in one group were placed on 4 gm aspirin daily for 5 days, and individuals in the other group were given placebo. Lymphocyte proliferation was measured before and 72 hours after the initiation of drug, by using three mitogens and four antigens. The percentages of T and B lymphocytes were likewise measured before and during therapy. The subjects were skin tested with the same four antigens 72 hours after the initiation of drug, and the skin tests were read 48 hours later. No significant differences between the two groups were detected when skin tests, lymphocyte proliferation, and percentage of T lymphocytes were compared.

References

Feb 1, 1977·Annals of the Rheumatic Diseases·A A AndrianakosJ Duffy
Feb 9, 1975·The New England Journal of Medicine·J E CroutR E Ritts
Oct 1, 1975·Annals of Internal Medicine·M J SmithK Davis
Sep 1, 1973·Lancet·P R Betts, I Forrest-Hay
Sep 1, 1973·Lancet·G OpelzA A Hirata
Aug 12, 1967·Lancet·I J Forbes, J L Smith
Jan 1, 1971·The Journal of Clinical Investigation·L M PachmanR D Peterson
Jun 1, 1954·The Biochemical Journal·P TRINDER

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Citations

Jun 1, 1987·Journal of the Neurological Sciences·J L TrotterJ D Scarpellini
Feb 1, 1989·Annals of the Rheumatic Diseases·M D SmithP J Roberts-Thomson
Dec 17, 2011·International Immunopharmacology·Muzammal HussainMuti Ur Rehman
Jun 2, 2012·Journal of Allergy·Dirk Schäfer, Steffen Maune
Feb 25, 2018·Veterinary Immunology and Immunopathology·T M ArcherA Mackin

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