Aspirin and platelet adenosine diphosphate receptor antagonists in acute coronary syndromes and percutaneous coronary intervention: role in therapy and strategies to overcome resistance

American Journal of Cardiovascular Drugs : Drugs, Devices, and Other Interventions
Jeremiah P Depta, Deepak L Bhatt

Abstract

Platelet activation and aggregation are key components in the cascade of events causing thrombosis following plaque rupture. Antiplatelet therapy is essential in the treatment of patients with acute coronary syndromes (ACS) and for those requiring percutaneous coronary intervention (PCI). Aspirin (acetylsalicylic acid) is a well established antiplatelet therapy and is mandated for secondary prevention of cardiovascular events following ACS. In patients with ACS, the addition of clopidogrel to aspirin is more effective than aspirin alone. For patients undergoing PCI, dual antiplatelet therapy with aspirin and clopidogrel is warranted. Aspirin should be continued indefinitely after PCI. Pretreatment of patients with clopidogrel prior to PCI lowers the incidence of cardiovascular events, yet the optimum timing of drug administration and dose are still being investigated, as is the duration of therapy following PCI. Late-stent thrombosis with drug-eluting stents has pushed the recommendation for duration of clopidogrel therapy up to 1 year and perhaps beyond, in patients without risks for bleeding. The concepts of aspirin and clopidogrel resistance are important clinical questions. No uniform definition exists for aspirin or clopid...Continue Reading

References

Feb 1, 1978·The Journal of Clinical Investigation·J W BurchP W Majerus
Jul 12, 1979·The New England Journal of Medicine·A R GrüntzigW E Siegenthaler
Aug 1, 1975·Proceedings of the National Academy of Sciences of the United States of America·G J RothP W Majerus
Sep 1, 1975·The Journal of Clinical Investigation·G J Roth, P W Majerus
Jul 1, 1991·British Journal of Clinical Pharmacology·A B HawthorneC J Hawkey
Aug 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·F CatellaG A FitzGerald
Mar 1, 1985·Clinical Pharmacokinetics·C J Needs, P M Brooks
Sep 1, 1985·Clinical Pharmacokinetics·F M Williams
Nov 28, 1985·The New England Journal of Medicine·J A CairnsM G Myers
Dec 1, 1985·Circulation·C PatronoL Forni
Sep 1, 1966·The American Journal of the Medical Sciences·A J Quick
Jun 1, 1982·The Journal of Clinical Investigation·P PatrignaniC Patrono
Dec 15, 1993·Proceedings of the National Academy of Sciences of the United States of America·J A MitchellJ R Vane
Mar 1, 1993·Journal of the American College of Cardiology·F C NathE J Topol
Feb 15, 1997·Lancet·A HaushoferH Prachar
Apr 3, 1997·The New England Journal of Medicine·P M RidkerC H Hennekens
May 24, 1997·Lancet·F J NeumannA Schömig
Sep 20, 1997·The American Journal of Cardiology·C Patrono, G Renda
May 20, 1998·American Heart Journal·N S NicholsonA K Salyers
Sep 12, 1998·Annals of Internal Medicine·P J SharisJ Loscalzo

❮ Previous
Next ❯

Citations

Oct 19, 2012·Current Opinion in Cardiology·Jeremiah P Depta, Deepak L Bhatt
Jan 7, 2015·Annual Review of Pharmacology and Toxicology·Jeremiah P Depta, Deepak L Bhatt
May 4, 2010·Journal of Endocrinological Investigation·I LambrinoudakiE Kouskouni
Mar 1, 2015·Personalized Medicine·Jeremiah P Depta, Sharon Cresci
Mar 13, 2021·The American Journal of Cardiology·Deepak L Bhatt, Charles V Pollack

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.