Aspirin-associated intracerebral hemorrhage in a patient with CADASIL

Clinical Neurology and Neurosurgery
Jung-Hwan OhJay Chol Choi

Abstract

Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is a hereditary disease characterized by ischemic stroke, cognitive impairment, migraine and neuropsychological deficit. Although intracerebral hemorrhage (ICH) has been described in patients with CADASIL, the cause of such ICH is still unknown. We present a 39-year-old man with CADASIL who had two years history of untreated hypertension. In this patient, acute ICH developed only two weeks after the initiation of aspirin. Brain images demonstrated a 3cmx3cm hyperacute ICH in the left temporal lobe at the site of previous old hemorrhage. The presence of cerebral microbleed and use of antithrombotics may be associated with development of ICH in patients with CADASIL.

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References

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Citations

May 4, 2013·Journal of the Neurological Sciences·Valentina RinnociLeonardo Pantoni
Jul 19, 2014·Neurology India·Qing-Che TanSheng-Yuan Yu
Feb 10, 2016·Journal of Stroke and Cerebrovascular Diseases : the Official Journal of National Stroke Association·Muhammad Taimoor KhanMatthew Smith
Aug 20, 2011·Journal of Stroke and Cerebrovascular Diseases : the Official Journal of National Stroke Association·Jay Chol ChoiJi-Hoon Kang
Dec 19, 2013·The Journal of Headache and Pain·Lifei LianSuiqiang Zhu
May 14, 2010·Arquivos de neuro-psiquiatria·Charles André
Feb 6, 2017·Continuum : Lifelong Learning in Neurology·Jennifer Juhl Majersik
Feb 13, 2009·Expert Review of Neurotherapeutics·Alberto del Río-EspínolaJoan Montaner
Nov 16, 2011·Internal Medicine·Yasuteru SanoTakashi Kanda
Apr 7, 2017·Annals of Clinical and Translational Neurology·Chen ZhangZaiqiang Zhang
Jan 20, 2021·Molecular Neurobiology·Arianna Manini, Leonardo Pantoni
Jan 23, 2021·Revue neurologique·P PalazzoJ-P Neau

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