Aspirin attenuates the initiation but not the progression of atherosclerosis in apolipoprotein E-deficient mice fed a high-fat, high-cholesterol diet

Basic & Clinical Pharmacology & Toxicology
Mònica TousJorge Joven

Abstract

Aspirin has potent antiinflammatory properties and attenuates atherosclerosis in apolipoprotein-E-deficient mice fed a high-fat, high-cholesterol diet. In an attempt to clarify the contradictory results obtained with normal chow, we studied the effect of aspirin for a prolonged period of time. The mice were fed a commercial chow until the experiment began at 8 weeks of age. Blood samples were then obtained and several mice (n=8) were sacrificed. The diet of the remaining 48 animals was supplemented with 200 g/kg palm fat and 1 g/kg cholesterol. They were then randomly divided into 2 groups, one of which received 0.5 mg/day of aspirin. The aspirin had a time-dependent effect. First, the extent of lesion decreased; then the effect was neutral; and, finally, after longer periods of being fed the atherogenic diet and receiving aspirin, the extent of the lesion increased. The transitory effect of aspirin should be elucidated in the absence of high dietary lipids.

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Citations

Feb 24, 2016·Clínica e investigación en arteriosclerosis : publicación oficial de la Sociedad Española de Arteriosclerosis·Marta Riera-BorrullJorge Joven
Mar 7, 2007·Expert Review of Cardiovascular Therapy·Sylvia HeenemanMat J A P Daemen
Oct 24, 2007·The Journal of Surgical Research·Shushan JacobSusan Lanza-Jacoby
Oct 21, 2011·Thrombosis and Haemostasis·D Lievens, P von Hundelshausen
Feb 9, 2012·British Journal of Clinical Pharmacology·Inge De MeyerGuido R Y De Meyer
Jan 6, 2011·Basic & Clinical Pharmacology & Toxicology·Apoorva SethiAnil Kumar
Mar 24, 2015·Frontiers in Immunology·Henry M NordingHarald F Langer
Oct 16, 2012·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·J JovenJ A Menéndez
Aug 26, 2014·Frontiers in Physiology·Philipp von Hundelshausen, Martin M N Schmitt
Nov 7, 2019·Science Translational Medicine·Tessa J BarrettJeffrey S Berger
Oct 2, 2019·Frontiers in Cardiovascular Medicine·Héloïse LebasYacine Boulaftali

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