PMID: 6106688Aug 1, 1980Paper

Aspirin binding and the effect of albumin on spontaneous and enzyme-catalysed hydrolysis

The Journal of Pharmacy and Pharmacology
L AaronsMalcolm Rowland

Abstract

A method of measuring the binding of aspirin to albumin without the interference of hydrolysis was developed. At concentrations of 10 mg litre-1, aspirin is about 85% bound to bovine serum albumin (4 g %), whereas its hydrolysis product, salicylic acid, is 95% bound. Salicylic acid was shown to displace aspirin from albumin binding sites. Both salicylic acid and aspirin bind more strongly to bovine serum albumin than to human serum albumin at protein concentrations of 4 g %. Protein binding protected aspirin against spontaneous hydrolysis although protein-bound aspirin still hydrolysed at a finite rate. In contrast, albumin enhanced the enzyme-catalysed hydrolysis of aspirin. By using a simple model, the rate constants for the individual processes contributing to the overall hydrolysis rate constant in the presence of albumin and esterase are calculated.

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Citations

Jan 1, 1989·Journal of Biochemical Toxicology·R Jarabak, J Westley
Nov 26, 2010·Journal of Pharmacokinetics and Pharmacodynamics·Michael S Roberts
Oct 24, 2002·Biochemical Pharmacology·Nicole A KratochwilPaul R Gerber
Nov 19, 2005·American Journal of Respiratory and Critical Care Medicine·Seung-Ha LeeChoon-Sik Park
Jun 15, 2013·Journal of Pharmaceutical Sciences·Raja GhoshSimon Lu
Mar 1, 1982·British Journal of Clinical Pharmacology·S A Adelusi, L A Salako
Oct 1, 1986·British Journal of Clinical Pharmacology·P P GodfreyD G Grahame-Smith
Apr 1, 1987·Journal of Clinical Pharmacology·R A KershawN Gerber
Aug 2, 2016·Biological & Pharmaceutical Bulletin·Akitoshi TatsumiSeigo Iwakawa
Nov 9, 2018·Frontiers in Cardiovascular Medicine·Jiayu Ye, Sanjoy Ghosh
Aug 2, 2017·Cancer Metastasis Reviews·Argentina OrnelasSteven Millward
Apr 1, 1987·Arthritis and Rheumatism·P B Costello, F A Green
Feb 24, 2020·Biochemical Pharmacology·Seo Woo KimRudi Beyaert

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