PMID: 11339623May 8, 2001Paper

Aspirin impairs antioxidant system and causes peroxidation in human erythrocytes and guinea pig myocardial tissue

Human & Experimental Toxicology
I DurakM Kaçmaz

Abstract

This study aims to investigate possible effects of aspirin treatment on cellular oxidant/antioxidant system. In the first part of the study, 15 guinea pigs were given aspirin at three different doses (2200, 440 and 10 mg/kg/day) for 30 days and five were fed on the same diet without aspirin. After a month, animals were killed and their hearts were removed for use in analyses. In the other part, after fasting blood samples were obtained from 11 volunteer subjects, they were given aspirin (approximately 10 mg/kg/day) for 30 days and second blood samples were obtained after 1 month. Five volunteer subjects also participated as placebo control. Oxidant/antioxidant parameters, namely superoxide dismutase (SOD), glutathione peroxidase (GSH-Px), catalase (CAT), malondialdehyde (MDA), nonenzymatic superoxide scavenger activity (NSSA), susceptibility to oxidation (SO) and antioxidant potential (AOP) values, were assayed in the samples. Antioxidant system was found to be impaired in the heart tissue from guinea pigs and in the erythrocytes from volunteer subjects. AOP and NSSA values were lower and MDA higher after aspirin treatment in both heart tissues and erythrocytes. In guinea pig heart tissue, SO was lower, but GSH-Px and CAT were ...Continue Reading

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Citations

Feb 29, 2008·Biological Trace Element Research·Vural KesikMehmet Gamsizkan
Feb 5, 2008·Clinica Chimica Acta; International Journal of Clinical Chemistry·M Y Burak Cimen
Feb 7, 2006·Free Radical Biology & Medicine·Manuela Gago-Dominguez, J Esteban Castelao
Jun 26, 2007·Acta Biologica Hungarica·A S FonsecaM Bernardo-Filho
May 2, 2003·Human & Experimental Toxicology·K DubeyK K Pillai
Aug 17, 2004·Epidemiology·Sander GreenlandJose Esteban Castelao
Oct 23, 2008·Journal of Environmental Science and Health. Part. B, Pesticides, Food Contaminants, and Agricultural Wastes·Ting LiYi Luo
Jul 20, 2002·Journal of Hypertension·John Quilley
Oct 11, 2013·Human & Experimental Toxicology·R AltintasZ R Duran
Jul 18, 2018·Dose-response : a Publication of International Hormesis Society·Modinat A AdefisayoKehinde P Olamilosoye
Jan 7, 2020·Daru : Journal of Faculty of Pharmacy, Tehran University of Medical Sciences·Olga I KulikovaTatiana N Fedorova

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