PMID: 9544970Apr 17, 1998Paper

Aspirin increases the bleeding side effects in essential thrombocythemia independent of the cyclooxygenase pathway: role of the lipoxygenase pathway

American Journal of Hematology
S CortelazzoM R Buchanan

Abstract

Acetylsalicylic acid (ASA) is currently recommended as an antithrombotic for patients with essential thrombocythemia (ET) who are at an increased risk of thrombotic events. However, ASA is also associated with an increased risk of bleeding in these patients as compared to the risk of bleeding in other patients treated with ASA. Recent data suggest that while ASA inhibits platelet thromboxane A2 (TxA2) synthesis in all individuals, ASA has little effect or inhibits the lipoxygenase pathway (i.e., 12-hydroxyeicosatetranoic acid or 12-HETE synthesis) in some individuals, and enhances 12-HETE synthesis in others. These differential effects are associated with a pronounced prolongation of the bleeding time vs. no prolongation of the bleeding time, respectively, i.e., in ASA responders and ASA nonresponders, respectively. To determine if the increased risk of ASA-induced bleeding seen in ET patients is associated with an effect on 12-HETE synthesis, we compared the relative effects of ASA on the bleeding time, platelet TxA2 and 12-HETE synthesis, and platelet aggregation and adhesion in ET patients and healthy volunteers. ASA (300 mg, taken orally) prolonged the bleeding time in 82% of the ET patients but only 27% of the healthy volu...Continue Reading

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Citations

May 3, 2014·Journal of Pharmaceutical and Biomedical Analysis·Isabella SquellerioViviana Cavalca
Aug 26, 2016·European Journal of Haematology·Péter DombiMiklos Egyed
Feb 14, 2002·British Journal of Haematology·Jerry L Spivak
Jan 29, 2005·Clinical and Applied Thrombosis/hemostasis : Official Journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis·Anna M Dyszkiewicz-KorpantyRavindra Sarode
Nov 2, 2013·Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis·Christoph RobierManfred Neubauer
Oct 28, 2015·Journal of the American Heart Association·Sandrine Ellero-SimatosUNKNOWN Pharmacometabolomics Research Network
Sep 24, 1999·The Medical Journal of Australia·M A BentleyS J Wright
Oct 31, 2002·Human Psychopharmacology·C. PerseganiM. Torlini
Mar 28, 2006·Blood Cells, Molecules & Diseases·Petro E Petrides, Fabian Siegel

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