Aspirin-induced gastric mucosal injury: lessons learned from animal models

Gastroenterology
G L Kauffman

Abstract

This review of the mechanisms by which aspirin causes gastric mucosal damage points to the involvement of two potential mechanisms. Aspirin, which inhibits cyclooxygenase, is rapidly deacetylated to salicylate. Salicylate is toxic to cells and affects mucosal barrier function, reduces cytosolic adenosine triphosphate, stimulates sodium transport, and increases proton dissipation from surface epithelial cells. Cyclooxygenase inhibition makes the gastric mucosa more susceptible to injury, inhibits mucus and bicarbonate secretion, alters the physicochemical nature of mucus, stimulates fundic but not antral [3H]thymidine incorporation, and reduces epithelial surface hydrophobicity. No single mechanism seems to be involved. It is likely, instead, that the toxic effects of salicylate and the effect of cyclooxygenase inhibition work in concert to render the mucosa more susceptible to injury, resulting in mucosal damage.

Citations

Jan 24, 2002·American Journal of Physiology. Gastrointestinal and Liver Physiology·Mia PhillipsonLena Holm
Aug 16, 2002·American Journal of Physiology. Gastrointestinal and Liver Physiology·Vittorio RicciRaffaele Zarrilli
Jan 20, 1999·Acta Paediatrica Japonica; Overseas Edition·T TomodaH Enzan
May 12, 2000·Alimentary Pharmacology & Therapeutics·Y MitobeA Terano
Jul 2, 2005·World Journal of Gastroenterology : WJG·George-V Papatheodoridis, Athanasios-J Archimandritis
Oct 23, 2010·The International Journal of Neuroscience·Ibrahim Sogut, Gungor Kanbak
Jan 1, 2004·Indian Journal of Clinical Biochemistry : IJCB·M N Astagimath, Shrinivas B Rao
Aug 1, 1991·Scandinavian Journal of Gastroenterology·L Aabakken
Sep 1, 1995·The Journal of Pharmacy and Pharmacology·K YokotaM Oda
Jan 1, 1995·Journal of Veterinary Internal Medicine·S A JohnstonM Marini
Aug 1, 1996·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·S K Kaan, C H Cho
Oct 29, 1998·The Journal of Small Animal Practice·S F ForsythJ Godfrey
Jun 24, 2010·The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi·Dong Keun ChoJong Sun Rew
Jan 1, 1991·Scandinavian Journal of Gastroenterology. Supplement·G P van Berge Henegouwen, A J Smout
Jul 1, 2002·Indian Journal of Clinical Biochemistry : IJCB·Arun RaySandip K Bandyopadhyay
Mar 27, 2003·International Journal of Experimental Pathology·Kamsiah JaarinA M Fauzee
Jul 22, 2010·Pharmaceutical Biology·Tawfeq Al-HowirinySyed Rafatullah
Feb 24, 2009·Toxicologic Pathology·Zaher A Radi
Jan 27, 2011·Digestion·Tetsuya TanigawaTetsuo Arakawa
Dec 24, 2002·Asia Pacific Journal of Clinical Nutrition·M I NafeezaM T Gapor
Dec 29, 2020·Journal of Ethnopharmacology·Gisele Goulart da SilvaAna Lucia Tasca Gois Ruiz
Mar 2, 2021·Acta Pharmaceutica Sinica. B·Dominik BakalarzMarcin Magierowski
Apr 5, 2000·Baillière's Best Practice & Research. Clinical Gastroenterology·A Lee
Feb 6, 1990·European Journal of Pharmacology·S J KonturekC Nauert
May 27, 2021·BioMed Research International·Mavis Boakye-YiadomEric Woode
Feb 9, 2005·Chemico-biological Interactions·Sanae Muraoka, Toshiaki Miura
Aug 3, 2001·Primary Care·D T SmootB Cryer
Aug 1, 1990·The American Journal of the Medical Sciences·M Feldman
May 1, 1997·Seminars in Veterinary Medicine and Surgery (small Animal)·M G Papich
Aug 10, 2000·The Veterinary Clinics of North America. Small Animal Practice·M G Papich
Sep 29, 2011·Disease-a-month : DM·Muhammed Sherid, Eli D Ehrenpreis

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