PMID: 6499Jul 1, 1976

Aspirin-induced gastritis and gastrointestinal bleeding

The Journal of the American Dental Association
A H Gartner

Abstract

Aspirin-induced gastritis and gastrointestinal hemorrhage were reviewed and discussed on the basis of currently available literature. Acute hemorrhagic gastritis occurs in from 50% to 70% of all patients taking aspirin, is not directly related to dose size, and can be severe enough to cause death in a few cases. No tolerance appears to ever develop. The mechanism that causes this bleeding is not definite, but the back diffusion of H+ ions accross the gastric barrier seems to bear primary responsibility, with physical erosion, prolonged platelet bleeding, and the effect of low pH values also being possible explanations. There appears to be less acid present in the stomach when bleeding occurs, but this is a masking effect of the aspirin that causes increased absorption of the H+ ions. Factors important in determining pharmaceutical formulation are method of administration, particle size of the aspirin, duration of contact between the drug and the mucosa, presence of buffers in the drug to raise the gastric pH, dissolution rate of the drug in the stomach, and ionization characteristics of the drug itself. Gastrointestinal blood loss caused by aspirin can be minimized by administering the drug in one of these forms:--a dilute solu...Continue Reading

References

Jun 1, 1969·American Journal of Surgery·R Menguy
Mar 1, 1972·Archives of Internal Medicine·J R Leonards, G Levy
Nov 1, 1972·Rheumatology and Physical Medicine·P N Bennett
Nov 8, 1973·The New England Journal of Medicine·J R LeonardsR Niemczura
Aug 12, 1974·JAMA : the Journal of the American Medical Association·J R Hoon
Jan 1, 1972·Annual Review of Medicine·R Menguy
Aug 9, 1969·British Medical Journal·A R Cooke, K Goulston
Dec 1, 1970·The International Journal of the Addictions·J Wenger, S Einstein
Jun 8, 1967·The New England Journal of Medicine·H W Davenport
Nov 1, 1958·British Medical Journal·L T STUBBE
Aug 1, 1961·The American Journal of Medicine·A WEISSE C GRAHAM

Citations

Jan 16, 2009·Journal of Gastroenterology and Hepatology·Hiroaki NemaMasahiro Asaka
Mar 23, 2017·British Journal of Pharmacology·Fatima IqbalDemidmaa Tuvdendorj

Related Concepts

Zorprin
Blood Platelets
Controlled-Release Preparations
Dose-Response Relationship, Drug
Epithelial Cells
Mesothelium
Structure of Pyloric Gland
Gastritis
Hematochezia
Hydrogen-Ion Concentration

Related Feeds

Atrophic Gastritis

Atrophic Gastritis is a process where gastric glandular cells are lost and replaced with firbous tissues, as a result of chronic inflammation. Learn more about Atrophic Gastritis here.