PMID: 7014935May 8, 1981Paper

Aspirin-induced prolongation of bleeding time and perioperative blood loss

JAMA : the Journal of the American Medical Association
P C AmreinW H Harris

Abstract

One hundred twenty-nine patients undergoing total hip replacement were treated with aspirin at a level of either 300 mg four times a day (1.2 g/day) or 900 mg four times a day (3.6 g/day). Baseline bleeding times before aspirin treatment averaged 4.18 +/- 1.44 minutes. Two hours after 300 mg and 900 mg of aspirin, the bleeding times were 5.83 +/- 1.88 and 5.72 +/- 1.57 minutes, respectively. After three to five days of aspirin therapy at 1.2 g/day and 3.6 g/day, the bleeding times were 6.27 +/- 2.27 and 6.43 +/- 2.11 minutes, respectively. The bleeding times for all the aspirin-treated groups were longer than baseline times. No paradoxical shortening of the bleeding time was noted at the 3.6-g/day dose. Perioperative blood loss for those receiving aspirin was not increased in six of eight subsets by operation and anesthesia when compared with historical control subjects. Neither a bleeding time greater than ten minutes nor a prolongation of the bleeding time by aspirin of more than four minutes over baseline bleeding times was associated with increased perioperative blood loss.

Citations

Dec 1, 1996·Journal of Travel Medicine·M N LeonF Fuentes
Oct 1, 1995·Journal of the American Academy of Dermatology·C C Otley, S M Olbricht
Nov 1, 1993·Journal of Clinical Anesthesia·N R Connelly, S Hall
Sep 1, 1983·Prostaglandins, Leukotrienes, and Medicine·M L DahlP Uotila
Jan 1, 1990·American Heart Journal·D R Hirsch, S Z Goldhaber
Oct 1, 2008·Acta Anaesthesiologica Scandinavica·T YokoyamaK Suwa
May 1, 1996·The Journal of the American Dental Association·M J Wahl, J Howell
Jan 1, 1988·The Annals of Thoracic Surgery·V A FerrarisW R Berry
Jul 2, 1999·The American Journal of Medicine·A I Schafer
Apr 5, 2005·Journal of the American College of Surgeons·Ronan A CahillH Paul Redmond
May 1, 1993·British Journal of Urology·A V Thurston, S L Briant
Feb 1, 1991·The Journal of Dermatologic Surgery and Oncology·S J Salasche, W J Grabski
Jul 1, 1990·British Journal of Urology·C J WatsonK N Bullock
Dec 1, 1994·Journal of the American Academy of Dermatology·C LawrenceS Tiling-Grosse
Jun 19, 2003·Clinical and Applied Thrombosis/hemostasis : Official Journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis·Christopher HoweAnil Potti
Jul 25, 2008·Journal of Dental Research·M T BrennanP B Lockhart
May 1, 1997·Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]·E M Billingsley, M E Maloney
Aug 26, 2006·Nature Clinical Practice. Neurology·Rafael H Llinas
Jul 4, 2002·European Journal of Anaesthesiology·A Tyagi, A Bhattacharya
Jul 1, 1987·Journal of General Internal Medicine·R Cygan, H Waitzkin
Jan 1, 1991·Archives of Orthopaedic and Trauma Surgery·P A Flordal, G Neander
Jun 1, 1996·Scandinavian Journal of Urology and Nephrology·M Y Ala-Opas, S S Grönlund
Dec 1, 1995·Scandinavian Journal of Urology and Nephrology·J P ZhuH H Meyhoff
Nov 24, 2005·Hematology·Amy A Hassan, Michael H Kroll

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