PMID: 7284679Apr 1, 1981

Aspirin inhibits the early myocardial release of thromboxane B2 and ventricular ectopic activity following acute coronary artery occlusion in dogs

British Journal of Pharmacology
S J CokerI J Zeitlin

Abstract

Acute coronary artery occlusion in anaesthetized open-chest greyhounds led to early release of thromboxane B2 (TxB2) into venous blood draining the ischaemic region. No release occurred from the remainder of the left ventricular wall (coronary sinus sampling). TxB2 release and ventricular ectopic activity were positively correlated (r = 0.863) 2 min post-occlusion. Aspirin (3 mg/kg i.v.) suppressed both local TxB2 release and ectopic activity and prevented ventricular fibrillation. It is suggested that TxB2 release is a factor contributing to early post-infarction arrhythmias.

Citations

May 1, 1988·Cardiovascular Drugs and Therapy·J R Parratt
May 1, 1985·Basic Research in Cardiology·S R JollyB R Lucchesi
Jan 1, 1992·European Journal of Clinical Pharmacology·R F BerntsenH Olsen
Nov 5, 1981·European Journal of Pharmacology·O Fagbemi, J R Parratt
Jan 1, 1990·Free Radical Biology & Medicine·M BernierD J Hearse
Apr 1, 1988·British Journal of Pharmacology·R M Tripathi, R Kaushal
Jan 11, 2001·Journal of Cardiovascular Pharmacology and Therapeutics·A A ShehadehT J Regan
Mar 1, 1985·Basic Research in Cardiology·I Leprán, A M Lefer

Related Concepts

Cardiac Arrhythmia
Zorprin
Coronary Heart Disease
Canis familiaris
Myocardium
Thromboxane B2
Thromboxanes

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