PMID: 8606328Feb 1, 1996Paper

Aspirin or acetaminophen? A comparison from data collected by the Spanish Drug Monitoring System

Journal of Clinical Epidemiology
A CarvajalL H Martin Arias

Abstract

To characterize and compare the toxicity profiles of aspirin and acetaminophen when used by large populations, all records of adverse drug reactions to these drugs reported to the Spanish Drug Monitoring System from 1982 to 1991 were analyzed. According to these data, aspirin-induced reactions were more serious than those reactions to acetaminophen; the severity of all the reactions in both cases was associated with time of exposure and with the accumulated dose administered. For GI reactions to aspirin no association was found between severity and time of exposure or dose, although an association with age was found. There were no differences between the proportions of deaths, malformations, and renal damage recorded for either of the two groups. Proportions of hematological and hepatic disturbances were greater with acetaminophen. Adverse drug reaction data for aspirin and acetaminophen from spontaneous reporting seem to be consistent with data coming from observational studies.

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Citations

May 26, 2004·Journal of Pain and Symptom Management·Sue Morgan, Saskie Dorman
Nov 13, 2001·American Journal of Therapeutics·R L Barkin
Jul 23, 2004·Expert Opinion on Drug Safety·Bernard Bannwarth
Sep 16, 2014·Expert Opinion on Drug Metabolism & Toxicology·Marzia LecchiPaolo Martelletti
Apr 6, 1999·Phytotherapy Research : PTR·M A RusuM Tămaş
Jun 5, 2018·British Journal of Clinical Pharmacology·J C McCraeD J Webb
Dec 12, 2001·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·A ConfortiG Velo
Jan 22, 2003·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·Roberto LeoneAnita Conforti
Feb 6, 2020·Biological & Pharmaceutical Bulletin·Yoichi IshitsukaDaisuke Kadowaki

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