Aspirin Recapitulates Features of Caloric Restriction

Cell Reports
Federico PietrocolaGuido Kroemer

Abstract

The age-associated deterioration in cellular and organismal functions associates with dysregulation of nutrient-sensing pathways and disabled autophagy. The reactivation of autophagic flux may prevent or ameliorate age-related metabolic dysfunctions. Non-toxic compounds endowed with the capacity to reduce the overall levels of protein acetylation and to induce autophagy have been categorized as caloric restriction mimetics (CRMs). Here, we show that aspirin or its active metabolite salicylate induce autophagy by virtue of their capacity to inhibit the acetyltransferase activity of EP300. While salicylate readily stimulates autophagic flux in control cells, it fails to further increase autophagy levels in EP300-deficient cells, as well as in cells in which endogenous EP300 has been replaced by salicylate-resistant EP300 mutants. Accordingly, the pro-autophagic activity of aspirin and salicylate on the nematode Caenorhabditis elegans is lost when the expression of the EP300 ortholog cpb-1 is reduced. Altogether, these findings identify aspirin as an evolutionary conserved CRM.

Citations

Jul 22, 2018·Circulation Research·Julio Madrigal-MatuteJunichi Sadoshima
Oct 26, 2018·Autophagy·Federico PietrocolaGuido Kroemer
Jan 17, 2019·Medicinal Research Reviews·Jan MartelJohn D Young
Mar 16, 2019·Cell Death & Disease·Valeria R VillellaLuigi Maiuri
Feb 6, 2020·Nature Reviews. Molecular Cell Biology·Weiqi ZhangJuan Carlos Izpisua Belmonte
Sep 11, 2019·Cardiovascular Research·Nina KaludercicJulio Madrigal-Matute
Jun 7, 2018·Oncotarget·Francesca CastoldiGuido Kroemer
Aug 8, 2018·Aging·Frank MadeoGuido Kroemer
Oct 12, 2019·Npj Aging and Mechanisms of Disease·Tugsan TezilEric Verdin
Jul 16, 2020·Apoptosis : an International Journal on Programmed Cell Death·Maurizio D BaroniEnzo Martegani
Nov 21, 2019·Molecular Medicine Reports·Ranjini SankaranarayananG Jayarama Bhat
Sep 17, 2020·Oncoimmunology·Julie Le NaourErika Vacchelli
Feb 8, 2019·Cell Death and Differentiation·Maria Chiara Maiuri, Guido Kroemer
Oct 28, 2019·Oncoimmunology·Federico Pietrocola, Guido Kroemer
Dec 8, 2019·Nutrients·Ki Wung Chung, Hae Young Chung
Jun 8, 2018·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Xiao-Bing HuangHuai-Rong Luo
Sep 5, 2018·Nature Reviews. Cardiology·Massimo BonoraLorenzo Galluzzi
Mar 13, 2019·Cell Death & Disease·Shaoyi ZhangGuido Kroemer
Feb 10, 2019·Cell Death & Disease·Luigi MaiuriGuido Kroemer
Apr 2, 2020·American Journal of Lifestyle Medicine·Ian D GrayPaul Wood
Apr 18, 2019·Scientific Reports·Gianluca FarrugiaRena Balzan
Apr 11, 2020·Frontiers in Cell and Developmental Biology·Guo ChenOliver Kepp
Jan 16, 2021·Journal of the American College of Cardiology·Panagiota Pietri, Christodoulos Stefanadis
Dec 11, 2020·Cell Death Discovery·Francesca CastoldiFederico Pietrocola
Dec 22, 2020·Ageing Research Reviews·Jan MartelDavid M Ojcius
Feb 20, 2021·Cell Death & Disease·Martina RaudenskáMichal Masařík
Feb 24, 2020·Biochemical Pharmacology·Seo Woo KimRudi Beyaert
Aug 3, 2020·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·A P Gómez-EscribanoR P Vázquez-Manrique
Oct 25, 2020·Cardiovascular Research·Sebastiano SciarrettaMaria Chiara Maiuri
May 2, 2021·Molecular Aspects of Medicine·Xin WenDaniel J Klionsky

❮ Previous
Next ❯

Methods Mentioned

BETA
acetylation
lipidation
transfection
immunoprecipitation
acetylate
transgenic
biosensor

Software Mentioned

Prism

Related Concepts

Related Feeds

Autophagy & Model Organisms

Autophagy is a cellular process that allows degradation by the lysosome of cytoplasmic components such as proteins or organelles. Here is the latest research on autophagy & model organisms