Aspirin response variability after major orthopedic surgery

Thrombosis Research
Chunjian LiJohn W Eikelboom

Abstract

Variability in platelet response to aspirin has been reported in patients undergoing cardiac surgery but has rarely been described in other operative settings and its mechanism remains uncertain. We performed a prospective cohort study to investigate the variability in platelet response to aspirin and to explore its mechanism in patients undergoing major orthopedic surgery. Twelve aspirin-treated patients undergoing elective hip or knee replacement were recruited. Once-daily aspirin was continued throughout the perioperative period. We measured platelet function using light transmission aggregation (LTA) in response to arachidonic acid (PL(AA)) and serum thromboxane B(2) (TXB(2)) at baseline (before surgery) as well as on days 1, 2, 3, 4, 5, 6, and 8 after surgery. We defined aspirin low response as a PL(AA)>20%. Six patients exhibited aspirin low response, which typically started on post-operative days 3 or 4; the remaining 6 patients had normal response to aspirin. Compared to aspirin responders, patients with aspirin low response showed significantly higher serum TXB(2) levels, a more pronounced early decrease in platelet count, and a significantly more rapid recovery of the platelet count after surgery. Aspirin response var...Continue Reading

Associated Clinical Trials

References

Jan 13, 2001·The Annals of Thoracic Surgery·L J DaceyUNKNOWN Northern New England Cardiovascular Disease Study Group
Mar 24, 2005·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·Norbert ZimmermannThomas Hohlfeld
Feb 21, 2006·Lancet·Graeme J Hankey, John W Eikelboom
Jun 24, 2006·Stroke; a Journal of Cerebral Circulation·Dermot CoxDesmond J Fitzgerald
Feb 27, 2007·Journal of Thrombosis and Haemostasis : JTH·S GuthikondaN S Kleiman
Oct 25, 2007·Platelets·Norbert ZimmermannThomas Hohlfeld
Apr 1, 2008·The Journal of Thoracic and Cardiovascular Surgery·Norbert ZimmermannThomas Hohlfeld
Jun 14, 2008·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·Grzegorz SuwalskiGrzegorz Opolski
Aug 14, 2009·European Journal of Clinical Investigation·J KempfertF W Mohr
Apr 10, 2010·Preventive Cardiology·Bryan C BordeauxDiane M Becker
Mar 8, 2012·Türk Kardiyoloji Derneği arşivi : Türk Kardiyoloji Derneğinin yayın organıdır·Durmuş Yıldıray SahinMustafa Demirtaş

❮ Previous
Next ❯

Citations

Nov 28, 2013·Journal of Vascular Surgery·Daniela CalderaroBruno Caramelli
May 27, 2020·Clinical and Applied Thrombosis/hemostasis : Official Journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis·Eugene KraussAyal Segal

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cardiovascular Disease Pathophysiology

Cardiovascular disease involves several different processes that contribute to the pathological mechanism, including hyperglycemia, inflammation, atherosclerosis, hypertension and more. Vasculature stability plays a critical role in the development of the disease. Discover the latest research on cardiovascular disease pathophysiology here.

Related Papers

European Journal of Vascular and Endovascular Surgery : the Official Journal of the European Society for Vascular Surgery
Sanne E HoeksDon Poldermans
JAMA : the Journal of the American Medical Association
Frank A LederleOpen Versus Endovascular Repair (OVER) Veterans Affairs Cooperative Study Group
The New England Journal of Medicine
Monique PrinssenDutch Randomized Endovascular Aneurysm Management (DREAM)Trial Group
© 2021 Meta ULC. All rights reserved