Aspirin-stimulated nitric oxide production by neutrophils after acute myocardial ischemia in rabbits

Circulation
López-FarréS Casado

Abstract

In recent studies, it has been hypothesized that the protective anti-ischemic effects of aspirin outweigh the effects of inhibition of platelet thromboxane A2 synthesis. Recently, we have found that the antiaggregating effects of aspirin significantly affect nitric oxide (NO) generation by neutrophils. The present study used circulating neutrophils from myocardial ischemic rabbits to assess the effect of aspirin on the circulating neutrophil-derived NO production and, subsequently, on the modulation of platelet activation. Neutrophils were obtained after 60 minutes of coronary artery occlusion followed by 60 minutes of reperfusion. Sham-operated animals were used as controls. The results demonstrated that aspirin stimulated the production of NO by neutrophils obtained from both sham-operated rabbits and rabbits with myocardial ischemia. However, neutrophils isolated from animals with myocardial ischemia showed an enhanced ability to generate NO in the presence of aspirin. As a functional in vitro marker, we observed that neutrophils had a NO-dependent, platelet-antiactivating effect in the presence of aspirin. In the absence of aspirin, ischemic neutrophils did not modify platelet activation, even though they produced increased...Continue Reading

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Citations

Apr 29, 1998·European Journal of Pharmacology·L Sánchez de MiguelA López-Farré
Feb 16, 2000·Obstetrics and Gynecology·M G DuránA López Farré
Mar 1, 2002·Journal of the American College of Cardiology·Lourdes Sánchez de MiguelAntonio López-Farré
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Aug 10, 2001·Plastic and Reconstructive Surgery·R H de Jong
Jan 4, 2012·Clinical and Experimental Pharmacology & Physiology·Ming ZhaoWei-Jin Zang
May 2, 2002·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·María M ArrieroJuan Carlos de la Pinta
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Jul 26, 2005·British Journal of Pharmacology·Laura MoleroCarlos Macaya
Oct 3, 2006·Expert Review of Neurotherapeutics·Masato Asanuma, Ikuko Miyazaki
Apr 23, 2002·Journal of the Renin-angiotensin-aldosterone System : JRAAS·A NúñezA López-Farré
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