Aspirin-triggered lipoxin A₄ attenuates lipopolysaccharide-induced intracellular ROS in BV2 microglia cells by inhibiting the function of NADPH oxidase.

Neurochemical Research
Yan WuYou Shang

Abstract

Lipoxins have emerged as mediators of key events in endogenous anti-inflammation and resolution. However, the implication of these novel lipid mediators on neuroinflammation has not been investigated. Microglia is the major cells involved in brain tissue damage during infection and neurodegenerative diseases. One of the major features shared by neuroinflammation conditions is the increased production of reactive oxygen species (ROS) generated by NADPH oxidase activation. In this study, we have examined whether aspirin-triggered lipoxin A(4) (ATL) modulates ROS generation in BV2 cells. Pre-treatment of BV2 cells with ATL blocked ROS production triggered by LPS in the time-dependent and concentration-dependent manner. ATL inhibited the translocation of the cytoplasmic NADPH oxidase subunit p47(phox) to the cell membrane as well as NADPH oxidase activity. Taken together, these results demonstrate that ATL suppresses NADPH oxidase-mediated ROS generation in BV2 microglia cells, strongly indicating that ATL may play an important role against the development and progression of neuroinflammtion.

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Citations

Dec 10, 2015·Oxidative Medicine and Cellular Longevity·Liang ZongHao Sun
Apr 10, 2016·Journal of Neuroinflammation·Alessandra Cadete MartiniGiles Alexander Rae
Jul 1, 2015·BMC Medicine·Sheila TsauSteven M LeVine
Oct 3, 2014·BioMed Research International·Alessandra Cadete MartiniGiles Alexander Rae
Oct 23, 2013·Neuroscience Research·Monty LymanDaqing Ma
Apr 21, 2017·Journal of the American Geriatrics Society·Nicola VeroneseMarco Solmi
Oct 22, 2013·The Journal of Pharmacy and Pharmacology·Sun Young ParkYoung-Whan Choi
Feb 18, 2014·Alzheimer's & Dementia : the Journal of the Alzheimer's Association·Xiuzhe WangMarianne Schultzberg
Dec 5, 2019·Molecular Nutrition & Food Research·Changmo KimJeremy M Sivak
Feb 22, 2017·Acta Pharmacologica Sinica·Ping-Ping LiuJing Zhao
Oct 3, 2018·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Ramin KhanabdaliBill Kalionis
Sep 18, 2020·Molecular Genetics and Metabolism Reports·Randall C MazzarinoGuido N Vacano
Nov 9, 2020·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Luísa Teixeira-SantosDora Pinho
Jun 17, 2021·PloS One·Jinyan WengUNKNOWN Alzheimer’s Disease Neuroimaging Initiative

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