PMID: 9556464Dec 16, 1998Paper

Aspirin use and colorectal cancer: post-trial follow-up data from the Physicians' Health Study

Annals of Internal Medicine
T StürmerC H Hennekens

Abstract

In contrast to most observational studies, the randomized Physicians' Health Study found no association between aspirin use and colorectal cancer after 5 years. To determine the effect of randomly assigned aspirin treatment and self-selected aspirin use on the incidence of colorectal cancer after 12 years and to identify factors influencing the self-selection of regular aspirin use. Randomized clinical trial and prospective cohort study. Male physicians throughout the United States. 22071 healthy male physicians who were 40 to 84 years of age in 1982. 325 mg of aspirin every other day. In 1988, the aspirin arm of the randomized trial was stopped early. Participants then chose to receive either aspirin or placebo for the rest of the study. Annual questionnaires asking about aspirin use and other variables, including occurrence of cancer. Colorectal cancer was diagnosed in 341 patients during the study period. Over 12 years of follow-up, random assignment to aspirin was associated with a relative risk for colorectal cancer of 1.03 (95% CI, 0.83 to 1.28). Various gastrointestinal symptoms and diagnoses were strong predictors of less frequent aspirin use in 1988. The relative risk for colorectal cancer in persons who used aspirin f...Continue Reading

Citations

Dec 18, 2001·International Journal of Cancer. Journal International Du Cancer·H Vainio
Apr 26, 2001·Journal of Surgical Oncology·G H EltabbakhC J Mettlin
Jul 15, 2006·Cancer Causes & Control : CCC·Cristina BosettiCarlo La Vecchia
Jun 20, 2007·Journal of General Internal Medicine·Elizabeth B LamontDiane S Lauderdale
Jul 20, 2007·Internal and Emergency Medicine·M Ponz de Leon, L Roncucci
Sep 12, 2000·Current Gastroenterology Reports·N Arber, R N DuBois
Oct 12, 2013·Current Oncology Reports·Mangesh A Thorat, Jack Cuzick
Nov 30, 2000·Current Treatment Options in Gastroenterology·R S Sandler
Oct 27, 2004·Critical Reviews in Oncology/hematology·J B TuynmanD J Richel
Sep 3, 1999·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·E Giovannucci
Oct 26, 1999·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·A K Kubba
May 2, 2000·Critical Reviews in Oncology/hematology·K KrishnanD E Brenner
Aug 7, 2003·Current Opinion in Pharmacology·Steven J ShiffDiana L Santini
Sep 20, 2001·International Immunopharmacology·F A Fitzpatrick
Apr 5, 2012·Nature Reviews. Clinical Oncology·Michael J ThunCarlo Patrono
Feb 24, 2001·Alimentary Pharmacology & Therapeutics·I Dove-Edwin, H J Thomas
Dec 17, 2009·Clinics in Colon and Rectal Surgery·Alyssa D Fajardo, Bruce W Robb
Jun 30, 2000·The New England Journal of Medicine·P A Jänne, R J Mayer
Mar 16, 2000·Journal of Women's Health & Gender-based Medicine·K M RexrodeJ E Buring
Mar 10, 2011·Annals of Oncology : Official Journal of the European Society for Medical Oncology·S-W OhUNKNOWN Korean Meta-analysis (KORMA) Study Group
Apr 21, 2012·Annals of Oncology : Official Journal of the European Society for Medical Oncology·C BosettiC La Vecchia
Oct 24, 2007·International Journal of Epidemiology·Enrico Flossmann, Peter M Rothwell
Oct 9, 2007·International Journal of Epidemiology·Richard Logan
Oct 28, 1998·Journal of the National Cancer Institute·S M LippmanA L Sabichi
Jun 8, 1999·Journal of the National Cancer Institute·J D Potter
Apr 19, 2007·Journal of the National Cancer Institute·María Elena Martínez, E Robert Greenberg
Oct 7, 2006·Current Opinion in Gastroenterology·D E Brenner
Oct 3, 1999·Current Opinion in Oncology·I Shureiqi, D E Brenner
Sep 6, 2001·European Journal of Cancer Prevention : the Official Journal of the European Cancer Prevention Organisation (ECP)·R BenamouzigUNKNOWN APACC Study Group. Association pour la Prevention par Aspirine du Cancer Colorectal
Nov 29, 2002·European Journal of Cancer Prevention : the Official Journal of the European Cancer Prevention Organisation (ECP)·C BosettiC La Vecchia
Aug 7, 2003·American Journal of Clinical Oncology·Asad UmarErnest T Hawk
Oct 23, 2008·European Journal of Cancer Prevention : the Official Journal of the European Cancer Prevention Organisation (ECP)·László HerszényiZsolt Tulassay
Aug 5, 2008·The Cancer Journal·Elizabeth B Lamont, Lauren E Dias
Apr 7, 2005·Postgraduate Medical Journal·S SanghaM M Wolfe
Apr 25, 2000·Annual Review of Medicine·J A Baron, R S Sandler
Dec 14, 2006·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Til StürmerRobert J Glynn
May 17, 2008·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Megan N HallJing Ma
Jul 29, 2006·Drugs & Aging·Michael HoffmeisterHermann Brenner
Apr 4, 2002·Drugs·Kate JollyMichael J S Langman
Aug 2, 2011·The British Journal of General Practice : the Journal of the Royal College of General Practitioners·Peter W RoseLucy S C Jenkins

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.