Aspirin use during pregnancy and the risk of bleeding complications: a Swedish population-based cohort study

American Journal of Obstetrics and Gynecology
Roxanne HastieLina Bergman

Abstract

Aspirin is offered to pregnant women to prevent preeclampsia, a severe obstetrical complication. Large studies of nonpregnant populations have consistently shown that aspirin prophylaxis increases the risk of hemorrhagic complications. However, there have not been any population-based studies investigating this in a pregnant population. This study aimed to investigate whether aspirin use during pregnancy is associated with an increased risk of bleeding complications. We performed a register-based cohort study using the Swedish Pregnancy Register wherein we examined 313,624 women giving birth between January 2013 and July 2017. Logistic regression was used to assess the risk of antepartum, intrapartum, and postpartum hemorrhage. A propensity score and inverse probability treatment weighting was used to generate an odds ratio that corrects for differences in baseline characteristics. Aspirin use was registered in 4088 (1.3%) women during pregnancy. Compared with women who did not take aspirin, aspirin use was not associated with bleeding complications during the antepartum period (adjusted odds ratio, 1.22; 95% confidence interval, 0.97-1.54). However, aspirin users had a higher incidence of intrapartum bleeding (2.9% aspirin use...Continue Reading

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Citations

Feb 10, 2021·Evidence-based Nursing·Hanumanthu R Jogu, Pradeep Yarra
Feb 24, 2021·Current Opinion in Obstetrics & Gynecology·Andrew R MatherLoralei L Thorburg
Mar 5, 2021·Drug and Therapeutics Bulletin·Stephen TongRoxanne Hastie
Mar 16, 2021·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Melanie NanaCatherine Nelson-Piercy
Jun 29, 2021·Current Treatment Options in Neurology·Deepa MalaiyandiKristin Guilliams
Aug 20, 2021·British Journal of Haematology·Eugene Oteng-NtimUNKNOWN British Society for Haematology Guideline
Sep 23, 2021·BJOG : an International Journal of Obstetrics and Gynaecology·Shiho OideTakashi Yoshioka

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