Aspirin Versus Aspirin Plus Clopidogrel as Antithrombotic Treatment Following Transcatheter Aortic Valve Replacement With a Balloon-Expandable Valve: The ARTE (Aspirin Versus Aspirin + Clopidogrel Following Transcatheter Aortic Valve Implantation) Randomized Clinical Trial

JACC. Cardiovascular Interventions
Josep Rodés-CabauMélanie Côté

Abstract

The aim of this study was to compare aspirin plus clopidogrel with aspirin alone as antithrombotic treatment following transcatheter aortic valve replacement (TAVR) for the prevention of ischemic events, bleeding events, and death. Few data exist on the optimal antithrombotic therapy following TAVR. This was a randomized controlled trial comparing aspirin (80 to 100 mg/day) plus clopidogrel (75 mg/day) (dual antiplatelet therapy [DAPT]) versus aspirin alone (single-antiplatelet therapy [SAPT]) in patients undergoing TAVR with a balloon-expandable valve. The primary endpoint was the occurrence of death, myocardial infarction (MI), stroke or transient ischemic attack, or major or life-threatening bleeding (according to Valve Academic Research Consortium 2 definitions) within the 3 months following the procedure. The trial was prematurely stopped after the inclusion of 74% of the planned study population. A total of 222 patients were included, 111 allocated to DAPT and 111 to SAPT. The composite of death, MI, stroke or transient ischemic attack, or major or life-threatening bleeding tended to occur more frequently in the DAPT group (15.3% vs. 7.2%, p = 0.065). There were no differences between groups in the occurrence of death (DA...Continue Reading

Citations

Oct 25, 2017·Future Cardiology·Mark MariathasNick Curzen
Apr 3, 2018·Cardiology in Review·Abdallah SanaaniJoseph M Harburger
May 1, 2018·Current Opinion in Cardiology·Homam IbrahimFrederick G P Welt
May 3, 2018·European Heart Journal·T J CahillB D Prendergast
Aug 31, 2018·EuroIntervention : Journal of EuroPCR in Collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology·Alexandra LanskyAndreas Baumbach
Mar 9, 2018·Catheterization and Cardiovascular Interventions : Official Journal of the Society for Cardiac Angiography & Interventions·Hitesh RahejaSamir Kapadia
Dec 12, 2018·Expert Review of Medical Devices·David Del ValJosep Rodés-Cabau
Jul 18, 2018·Minerva cardioangiologica·Arthur Shiyovich, Ran Kornowski
Dec 21, 2018·Circulation. Cardiovascular Interventions·Chekrallah ChamandiSiamak Mohammadi
Jan 12, 2019·Circulation. Cardiovascular Interventions·Paul GuedeneyGeorge D Dangas
Apr 11, 2018·Current Treatment Options in Cardiovascular Medicine·Ricardo Cigarroa, Sammy Elmariah
Apr 9, 2019·Circulation Journal : Official Journal of the Japanese Circulation Society·In-Chang HwangHyo-Soo Kim
May 8, 2019·Catheterization and Cardiovascular Interventions : Official Journal of the Society for Cardiac Angiography & Interventions·Homam IbrahimMathew R Williams
Jun 19, 2019·JAMA : the Journal of the American Medical Association·Chetan P HudedSamir R Kapadia
Sep 21, 2019·EuroIntervention : Journal of EuroPCR in Collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology·Ben WilkinsLars Søndergaard
Nov 10, 2017·Pharmacotherapy·Bethany A KalichIan B Hollis
Oct 15, 2019·Catheterization and Cardiovascular Interventions : Official Journal of the Society for Cardiac Angiography & Interventions·Toshiki KunoSripal Bangalore
Nov 28, 2019·Seminars in Cardiothoracic and Vascular Anesthesia·Ilankumaran KaliamoorthyMohamed Rela
Sep 6, 2019·The Journal of Cardiovascular Surgery·Xiaochun MaZhengjun Wang
Dec 29, 2019·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·Yuexin ZhuQingchun Zeng
Apr 1, 2020·Diagnostics·Francesco NappiFerdinando Auricchio
Mar 9, 2019·Heart·Karim Al-AziziMichael Mack
Mar 15, 2019·Heart·Vincent Johan NijenhuisJurrien Maria Ten Berg
Jan 26, 2018·European Journal of Heart Failure·Noman AliSteven J Lindsay
Aug 11, 2018·Current Cardiology Reports·Sasha StillMichael Mack
Sep 1, 2020·The New England Journal of Medicine·Jorn BrouwerJurriën M Ten Berg
Apr 6, 2019·Proceedings·Jerry FanTimothy Mixon
Mar 18, 2020·European Cardiology·Leslie Marisol LugoJosé Luis Ferreiro
Apr 13, 2018·Frontiers in Cardiovascular Medicine·Cécile OuryJutta Bergler-Klein
Jul 6, 2018·Nature Reviews. Cardiology·Davide CapodannoDominick J Angiolillo
Apr 6, 2018·Circulation Journal : Official Journal of the Japanese Circulation Society·Hashrul N RashidRobert P Gooley
Jun 15, 2019·Expert Review of Cardiovascular Therapy·Antonio GrecoDavide Capodanno
Sep 18, 2020·Journal of Cardiac Surgery·Joel AikinsAmer Harky
Sep 16, 2020·European Heart Journal·Arnold C T NgJeroen J Bax
Aug 16, 2018·Frontiers in Cardiovascular Medicine·German ArmijoGabriela Tirado-Conte
Jun 20, 2019·Frontiers in Cardiovascular Medicine·Roberto ValvoMarco Barbanti
Jun 20, 2020·Expert Review of Cardiovascular Therapy·Antonio Giulio BrunoFrancesco Saia

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