Asprosin: A Novel Player in Metabolic Diseases.

Frontiers in Endocrinology
Mingyang YuanJing Wu

Abstract

Asprosin, a novel glucogenic adipokine, is encoded by two exons (exon 65 and exon 66) of the gene Fibrillin 1 (FBN1) and mainly synthesized and released by white adipose tissue during fasting. Asprosin plays a complex role in the central nervous system (CNS), peripheral tissues, and organs. It is involved in appetite, glucose metabolism, insulin resistance (IR), cell apoptosis, etc. In this review, we will summarize the newly discovered roles of asprosin in metabolic diseases including diabetes, obesity, polycystic ovarian syndrome (PCOS), and cardiovascular disease (CVD), which may contribute to future clinical diagnosis and treatment.

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Citations

May 20, 2020·Archives of Physiology and Biochemistry·Halil İbrahim Ceylan, Özcan Saygın
Jan 9, 2021·International Journal of Endocrinology·Xiaoan KeHuijuan Zhu
Nov 24, 2020·Diabetes, Metabolic Syndrome and Obesity : Targets and Therapy·Xia DengGuoyue Yuan
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Mar 14, 2021·Biochimica Et Biophysica Acta. Molecular Basis of Disease·Julliane Tamara Araújo de Melo CamposJosivan Gomes Lima
Mar 30, 2021·Hormone Molecular Biology and Clinical Investigation·Rasim MogulkocAbdullah Sivrikaya
Apr 4, 2021·International Journal of Molecular Sciences·Ana Rita de Oliveira Dos SantosJesselina F Dos Santos Haber
Aug 29, 2020·Journal of Agricultural and Food Chemistry·Ju HuQinwan Huang

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Methods Mentioned

BETA
MDA

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