PMID: 9534916Apr 16, 1998Paper

Assay for detecting IgE and IgG antibodies against Candida albicans cell-wall mannan

Allergy
Kazuo AkiyamaH Kato

Abstract

In the present study, we assayed mannan-specific IgE and IgG antibodies in samples of serum isolated from blood collected from adult patients with bronchial asthma, using a liquid-phase method with a polysaccharide, mannan (Mn), purified from Candida albicans (C. alb), and investigated the relationships of allergenicity among a crude extract of C. alb, purified Mn, and acid protease (AP), The correlations between the titers of anti-Mn A and anti-Mn B IgE and IgG were very strong, and the levels of inhibition of anti-Mn A IgE and IgG reactions by Mn A and Mn B were almost identical. Although no common allergenicity was observed between Mn A and AP because there was no correlation between the titers of anti-Mn A and anti-AP IgE, and no inhibition of the anti-Mn A IgE reaction by AP, both antigens were found to exist in crude C. alb. The level of inhibition of anti-crude C. alb IgG reaction by Mn A or Mn B was about 60%. Approximately 70% inhibition of the anti-Mn A IgE reaction was observed for eight different fungal allergen extracts, but no inhibition was observed for 11 of the other fungal allergen extracts tested. The above results indicate that common antigenicity was observed between Mn A and Mn B in the human IgE and IgG a...Continue Reading

References

Jan 1, 1992·Microbiology and Immunology·H MukaiH Yamaguchi
Jan 1, 1992·Microbiology and Immunology·T YamamotoH Yamaguchi
Aug 30, 1974·Mycopathologia et mycologia applicata·T TsuchiyaT Shinoda
Dec 1, 1996·Allergy·K AkiyamaH Yamaguchi
Oct 1, 1961·Journal of Bacteriology·H F HASENCLEVER, W O MITCHELL

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Citations

Oct 24, 2008·Phytopathology·F M DoohanP Nicholson
May 12, 2009·Nihon Ishinkin Gakkai zasshi = Japanese journal of medical mycology·Kazuo Akiyama, Masami Taniguchi

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