PMID: 6167829Sep 5, 1981Paper

Assay of an interferon-induced enzyme in white blood cells as a diagnostic aid in viral diseases

Lancet
A SchattnerM Revel

Abstract

Interferon is part of the system of defence against viral infections and has important cell-regulatory and immunoregulatory functions. It is, however, not always possible to quantify circulating interferon in patients. An assay has been developed to measure an interferon-induced enzyme in white blood cells. The activity of this enzyme is constant in healthy subjects but increases by 2-10 times in 85% of patients with acute viral infections. It is also enhanced in autoimmune diseases and in virus-related malignancies and neurological disorders. The enzyme level was not raised in bacterial infections or non-infectious diseases studied. This simple and rapid biochemical assay of the interferon system could be used for diagnosis and evaluation of many diseases.

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Citations

Mar 1, 1983·European Journal of Pediatrics·S Levin
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Sep 1, 1988·The American Journal of Medicine·A SchattnerM Revel
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