PMID: 2100623Jan 1, 1990Paper

Assay of caffeine metabolism in vitro by human liver microsomes using radio-high-performance liquid chromatography

Journal of Pharmaceutical and Biomedical Analysis
F ValeroJ Segura

Abstract

The low turnover of caffeine in vitro by human liver microsomes makes the study of the metabolic pathways of this compound difficult. Analytical methods with high sensitivity and specificity are needed for the detection of its metabolic products. A method based on the on-line radiometric determination of [8C-3H]caffeine and its principal metabolite (paraxanthine) in man has been developed using reversed-phase high-performance liquid chromatography. The method has been successfully employed in preliminary studies of the kinetics of this reaction.

References

Jun 1, 1990·British Journal of Clinical Pharmacology·D SesardicD S Davies
Jan 1, 1984·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·E RennerR Preisig

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Citations

May 1, 1994·British Journal of Clinical Pharmacology·C CazeneuveG Olive
Sep 1, 1995·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·J C BloomerR J Chenery
Jun 1, 1994·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·S E ClarkeR J Chenery
Jan 16, 1999·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·S E Clarke

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