Assay of effervescent tablets by near-infrared spectroscopy in transmittance and reflectance mode: acetylsalicylic acid in mono and combination formulations

Journal of Pharmaceutical and Biomedical Analysis
P Merckle, K A Kovar

Abstract

Near-infrared spectroscopy (NIRS) was used to determine acetylsalicylic acid (ASA) in three different effervescent tablet formulations. The nominal ASA concentrations were 14.9% in the single substance formulation (ASA Mono), 17.4% in the combination with ascorbic acid (ASA + C) and 8.7% in the combination with paracetamol and ascorbic acid (ASA Combi). In each case the tablet matrix was composed of seven excipients typical of effervescent tablets. All three formulations were measured as intact tablets in diffuse transmittance and reflectance and as powdered tablets in diffuse reflectance. Calibration was carried out by partial least square (PLS) regression of second derivative spectra. High-performance liquid chromatography (HPLC) was used as the reference method. The relative standard errors of calibration (RSEC) achieved for the three NIR methods were between 1.20 and 2.01% for ASA Mono, between 1.91 and 2.21% for ASA + C and between 2.41 and 4.50% for ASA Combi. The results obtained in transmittance mode were comparable with those obtained in reflectance mode, which is normally used in NIRS. In the test sets of ASA Mono and ASA + C relative root mean square (RRMS) values between 2.21 and 3.13% were obtained. The three NIR m...Continue Reading

Citations

May 19, 2005·Advanced Drug Delivery Reviews·Gabriele Reich
Feb 19, 2000·Forensic Science International : Synergy·N Sondermann, K A Kovar
Jan 20, 2004·AAPS PharmSciTech·J L RamirezR J Romañac
Aug 12, 2014·Analytical and Bioanalytical Chemistry·Eva WoltmannCarolin Huhn
Sep 18, 2008·Pharmaceutical Development and Technology·A CournoyerN Abatzoglou
Aug 21, 2016·International Journal of Pharmaceutics·Pallavi PawarFernando Muzzio
Mar 29, 2014·Applied Spectroscopy·Nicola KellichanGary McGeorge
Jul 4, 2001·Analytical Chemistry·R K Gilpin, L A Pachla

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