Assay of ischemia-modified albumin and C-reactive protein for early diagnosis of acute coronary syndromes.

Journal of Clinical Laboratory Analysis
Cui LiyanHu Xiaozhou

Abstract

Diagnosis of cardiac ischemia in patients coming to emergency departments (ED) with symptoms of acute chest pain is often difficult. Many markers are sensitive and specific for the detection of myocardial necrosis but may not rise during reversible myocardial ischemia. Ischemia-modified albumin (IMA) has recently been shown to be a sensitive and early biochemical marker of ischemia. The variation laws were observed by measuring IMA and C-reactive protein (CRP) of 113 patients in ED within 12 hr after onset of chest pain. In the observation, blood was taken for IMA and CRP. Patients underwent standardized triage, diagnostic procedures, and treatment. Results of IMA and CRP were correlated with final diagnoses of nonischemic chest pain (NICP) and acute coronary syndrome (ACS). There were obvious distinction of IMA and CRP levels between the NICP and ACS groups. Receiver operator characteristic (ROC) curve analysis was used to determine the optimal cutoff of this assay for identifying individuals with ACS patients from NICP. The area under the curves of IMA is 0.948. The sensitivity and specificity of albumin cobalt binding (ACB) at a cutoff value of 70.0 units/mL were 94.4% and 82.6%, respectively. The area under the curves of CR...Continue Reading

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Citations

Jun 28, 2011·International Journal of Emergency Medicine·Deborah B DiercksEzra A Amsterdam
Sep 18, 2012·Revista española de medicina nuclear e imagen molecular·Z P KocO Saka
Mar 6, 2010·International Journal of Cardiology·Xiao-Li ShenXiao-Dong Pu
Jul 25, 2009·Clinica Chimica Acta; International Journal of Clinical Chemistry·Konstantinos KazanisAmalia Dionyssiou-Asteriou
Feb 13, 2013·Journal of Clinical Laboratory Analysis·Aysun TokerKürşat Akbuğa
Jan 19, 2010·Academic Emergency Medicine : Official Journal of the Society for Academic Emergency Medicine·Sandrine CharpentierDominique Lauque
Aug 1, 2008·Molecular & Cellular Proteomics : MCP·Alistair V G EdwardsStuart J Cordwell
Apr 7, 2018·The Egyptian Heart Journal : (EHJ) : Official Bulletin of the Egyptian Society of Cardiology·Mohamed Abdel Kader Abdel Wahab

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