PMID: 7541527Jul 1, 1995Paper

Assay variability in serum prostate-specific antigen determination

The Prostate
M K BrawerM H Wener

Abstract

Consistency and reproducibility of serum prostate-specific antigen (PSA) measurement are essential in the application of this analyte to early detection or screening programs. In the present investigation, we sought to compare serum PSA levels determined by the IMx assay (Abbott Laboratories, North Chicago, IL) and the Tandem E (Hybritech Inc., San Diego, CA) to determine whether there were differences. Two hundred twenty-eight random sera from our archival bank were investigated. One hundred-eight specimens were in the Tandem range of 2.0-10.0 ng/ml, and prostatic histology was known based on either systematic sector needle biopsy or transurethral resection. PSA was measured with three different lost of the IMx and Tandem assays. Over the entire range, there was a good correlation (r2 = 0.985); however, in the more useful clinical range of 2.0-10.0 ng/ml, the correlation was reduced to 0.923; in the 2.0-6.0 ng/ml range, it was further reduced to 0.852. The slope for the entire range was 0.948; however, in the 2.0- to 10.0-ng/ml range, it was 0.894; in the 2.0- to 6.0-ng/ml range, the slope was 0.815. Using PSA cutoffs of 4.0, 5.0, and 6.0 ng/ml, significant decrease in abnormal PSA values in men with cancer was observed with t...Continue Reading

References

Mar 1, 1992·The Journal of Urology·M K BrawerP H Lange
Apr 22, 1992·JAMA : the Journal of the American Medical Association·H B CarterP C Walsh
Mar 1, 1992·The Journal of Urology·J P Jarow, A J DeFranzo
Apr 25, 1991·The New England Journal of Medicine·W J CatalonaG L Andriole
Jan 1, 1994·The Journal of Urology·G G KleeJ E Oesterling
Aug 25, 1993·JAMA : the Journal of the American Medical Association·W J CatalonaJ W Basler
Feb 1, 1993·The Journal of Urology·G S Gerber, H W Schoenberg

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Citations

Jun 27, 2002·Current Urology Reports·K Okihara, R J Babaian
Jul 29, 1998·The Journal of Urology·R G NixonM K Brawer
May 9, 2003·The Urologic Clinics of North America·Peter W SwindlePeter T Scardino
Oct 6, 1998·Critical Reviews in Clinical Laboratory Sciences·H G RittenhouseA W Partin

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