Assaying the Potency of Influenza Vaccines

Vaccines
Philip D Minor

Abstract

The potency of vaccines must be determined to ensure that the appropriate dose is given. The manufacture and assessment of influenza vaccines are complicated by the continuously changing nature of the pathogen, which makes efficacy estimates difficult but also confounds attempts to produce a well-validated, consistent potency assay. Single radial diffusion has been used for decades and provides a relatively simple way to measure the amount of biologically active materials present in the vaccine. It requires reagents, which are updated on a regular, frequently yearly, basis and alternative methods continue to be sought.

References

Apr 9, 2002·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Paul K S Chan
Oct 28, 2009·Vaccine·C Estmer NilssonA Frostell-Karlsson
Jul 9, 2011·Science·Damian C EkiertJaap Goudsmit
Jan 17, 2012·Biologicals : Journal of the International Association of Biological Standardization·Ruth HarveyOthmar G Engelhardt
Dec 22, 2012·The Lancet Infectious Diseases·Angus Nicoll, Marc Sprenger
Aug 5, 2014·Influenza and Other Respiratory Viruses·Falko SchmeisserJerry P Weir

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Citations

Mar 7, 2017·Vaccine·Laura R KuckKathy L Rowlen
Mar 5, 2017·Journal of Virological Methods·Hongquan WanMaryna C Eichelberger
Jan 23, 2018·Influenza and Other Respiratory Viruses·John M Wood, Jerry P Weir
Jan 16, 2018·Bioanalysis·Thorsten VerchMary Shank-Retzlaff
Aug 5, 2017·Frontiers in Immunology·Shahzma MeraniJanet E McElhaney
Oct 17, 2018·NPJ Vaccines·Rose T Byrne-NashKathy L Rowlen
Oct 8, 2020·Biologicals : Journal of the International Association of Biological Standardization·Hitoshi TakahashiEri Nobusawa
Sep 23, 2021·Expert Review of Vaccines·Robin H G A van den BiggelaarChristine A Jansen

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Methods Mentioned

BETA
ELISA
chip

Software Mentioned

InDvr

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