Assembling patchy plasmonic nanoparticles with aggregation-dependent antibacterial activity.

Journal of Colloid and Interface Science
Francesco BrasiliFabio Domenici

Abstract

We realise an antibacterial nanomaterial based on the self-limited assembly of patchy plasmonic colloids, obtained by adsorption of lysozyme to gold nanoparticles. The possibility of selecting the size of the assemblies within several hundred nanometres allows for tuning their optical response in a wide range of frequencies from visible to near infrared. We also demonstrate an aggregation-dependent modulation of the catalytic activity, which results in an enhancement of the antibacterial performances for assemblies of the proper size. The gained overall control on structure, optical properties and biological activity of such nanomaterial paves the way for the development of novel antibacterial nanozymes with promising applications in treating multi drug resistant bacteria.

Citations

Dec 29, 2020·International Journal of Biological Macromolecules·Debora CapraraPaolo Postorino

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